{"created":"2023-05-15T08:55:46.547706+00:00","id":997,"links":{},"metadata":{"_buckets":{"deposit":"fb93af5c-0c3e-4890-816b-5362c95e2890"},"_deposit":{"created_by":10,"id":"997","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"997"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00000997","sets":["100:101:103:149"]},"author_link":["755"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 歯肉炎により歯肉溝の LDLが酸化 LDL (oxLDL) に変化することに着目し、oxLDLの石灰化能を検証した。本研究では糖質、脂質、タンパク質についてカルシウム沈着能力の変化をモニタリングした。その結果、各種糖質、タンパク質について、濃度と分子量を変えてもカルシウム沈着の促進は見られなかった。しかし、酸化LDL(oxLDL)を加えた実験系では、添加したoxLDLの濃度依存的にカルシウム沈着の促進が認められた。電子顕微鏡によるカルシウム沈着の所見でもoxLDLのカルシウム沈着能力が証明できた。このことから、oxLDLがフッ化物とは異なる機序の抗齲蝕製剤として機能する可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Focusing on the oxidation of LDL in the gingival crevicular fluid due to gingivitis, we hypothesized that oxidized LDL (oxLDL) deposits supersaturated calcium on the tooth surface. In this study, change in calcium deposition level were monitored for carbohydrates, lipids, and proteins. As a result, no promotion of calcium deposition was observed even when the concentration and molecular weight of various carbohydrates and proteins were changed. However, in the experimental system to which oxLDL was added, the promotion of calcium deposition was observed depending on the concentration of the added oxLDL. Electron microscopic findings also demonstrated the calcification ability of oxLDL. These data suggest that oxLDL may function as an anti-cariogenic preparation by a different mechanism from that of fluoride.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2020(令和2)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2018-04-01 – 2021-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔衛生学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 本研究により酸化 LDL (oxLDL) のカルシウム沈着能力が示された。歯肉溝の LDLが慢性炎症によりoxLDLに変化することで、脱灰歯面の再石灰化が促進される。このことは、oxLDLがフッ化物とは異なる機序の抗齲蝕製剤として機能する可能性を意味している。しかし、同時に歯肉溝においてoxLDLの働きで歯石が形成される可能性がある。従来から、歯周病と糖尿病や内臓脂肪症候群の関連性が示唆されている。本研究により歯科診療所で糖尿病や内臓脂肪症候群を積極的に予防し、血液や歯肉溝の LDLやoxLDLの濃度を常時抑えることが歯周病の予防戦略として必要であることが明らかになった。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 18K09926","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K09926/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-02"}],"displaytype":"detail","filename":"18K09926.pdf","filesize":[{"value":"279.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"18K09926","url":"https://tsurumi-u.repo.nii.ac.jp/record/997/files/18K09926.pdf"},"version_id":"7753059c-6f84-4550-9480-e0663bf0d638"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"酸化脂質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"LDL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HDL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"齲蝕","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"根面齲蝕","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化LDL","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"石灰化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯石","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"HANADA, Nobuhiro","creatorNameLang":"en"},{"creatorName":"花田, 信弘","creatorNameLang":"ja"},{"creatorName":"ハナダ, ノブヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"HANADA","familyNameLang":"en"},{"familyName":"花田","familyNameLang":"ja"},{"familyName":"ハナダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Nobuhiro","givenNameLang":"en"},{"givenName":"信弘","givenNameLang":"ja"},{"givenName":"ノブヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"755","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70180916","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70180916"},{"nameIdentifier":"755","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"酸化脂質を用いた新しい根面齲蝕の予防方法の開発とフッ化物併用療法への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸化脂質を用いた新しい根面齲蝕の予防方法の開発とフッ化物併用療法への応用","subitem_title_language":"ja"},{"subitem_title":"Development of a new preventive method for root caries using lipid oxide and its application to fluoride combination therapy","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["149"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-02"},"publish_date":"2022-03-02","publish_status":"0","recid":"997","relation_version_is_last":true,"title":["酸化脂質を用いた新しい根面齲蝕の予防方法の開発とフッ化物併用療法への応用"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:02:04.665873+00:00"}