{"created":"2023-05-15T08:55:46.140607+00:00","id":989,"links":{},"metadata":{"_buckets":{"deposit":"d6a7377c-e83d-4b53-a8b1-cef5e9ccc635"},"_deposit":{"created_by":10,"id":"989","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"989"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00000989","sets":["100:101:103:149"]},"author_link":["747"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、不正咬合モデルマウスを作製し、口腔疾患と心疾患の因果関係およびその分子機序を解明することを目的とした。16週齢の雄性マウスを①コントロール群、②不正咬合群、③propranolol（β受容体遮断薬）投与群、④不正咬合＋propranolol投与群の4群に分けて2週間後に心臓を摘出し、不正咬合による口腔ストレスが心臓および交感神経活動に及ぼす影響を詳細に解析した。その結果から、不正咬合による慢性的な交感神経活動の亢進が、細胞内Ca2+の過負荷ならびにオートファジー機能の低下による酸化ストレスの上昇を介して心筋リモデリング（線維化およびアポトーシス）を誘導することが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）： Various types of stress are associated with increased incidence of cardiovascular disease, but the relationship between occlusal disharmony and cardiovascular disease remain poorly understood. Therefore, in this work, we examined the effects of occlusal disharmony on cardiac homeostasis in bite-opening (BO) mice, in which a 0.7 mm space was introduced by cementing a suitable appliance onto the mandibular incisor. Sympathetic nervous activity and serum corticosterone, a key biomarker for stress, were significantly increased by the 14 days of BO treatment. Cardiac function was significantly decreased by the BO treatment, but propranolol, a non-selective β-blocker, ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage were significantly increased by the BO treatment, but propranolol blocked these changes. These results suggest that occlusal disharmony might affect cardiac homeostasis via alteration of the autonomic nervous system.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2020(令和2)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2017-04-01 – 2021-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：生理学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 口腔疾患と心疾患の関連性は疫学調査から示唆されているが、その因果関係やメカニズムに関する詳細な報告は少ない。本研究では、不正咬合モデルマウスを用い、口腔機能障害と心疾患の因果関係およびその分子機序を解明した。また、得られた研究成果から、正常な口腔機能の維持が心疾患の予防につながることも示唆された。高齢化社会を迎え、近年増加傾向にある歯周病などの口腔疾患と、死亡原因第2位の心疾患との関連性を調べた本研究の意義はきわめて高い。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 17K12067","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K12067/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-02"}],"displaytype":"detail","filename":"17K12067.pdf","filesize":[{"value":"269.6 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"17K12067","url":"https://tsurumi-u.repo.nii.ac.jp/record/989/files/17K12067.pdf"},"version_id":"51c782b1-9765-4886-9913-ee7ba4c3ae9e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"不正咬合","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"線維化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"オートファジー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"プロプラノロール","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"OHNUKI, Yoshiki","creatorNameLang":"en"},{"creatorName":"大貫, 芳樹","creatorNameLang":"ja"},{"creatorName":"オオヌキ, ヨシキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OHNUKI","familyNameLang":"en"},{"familyName":"大貫","familyNameLang":"ja"},{"familyName":"オオヌキ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoshiki","givenNameLang":"en"},{"givenName":"芳樹","givenNameLang":"ja"},{"givenName":"ヨシキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"747","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50288114","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50288114"},{"nameIdentifier":"747","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔疾患と心疾患の関連性の解明―心不全の非薬物治療法開発の基礎的研究―","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔疾患と心疾患の関連性の解明―心不全の非薬物治療法開発の基礎的研究―","subitem_title_language":"ja"},{"subitem_title":"Effects of oral disease on cardiac function","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["149"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-02"},"publish_date":"2022-03-02","publish_status":"0","recid":"989","relation_version_is_last":true,"title":["口腔疾患と心疾患の関連性の解明―心不全の非薬物治療法開発の基礎的研究―"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T07:39:24.008128+00:00"}