{"created":"2023-05-15T08:55:46.094364+00:00","id":987,"links":{},"metadata":{"_buckets":{"deposit":"8150a7f3-53ae-42dd-b72e-31063bd869fb"},"_deposit":{"created_by":10,"id":"987","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"987"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00000987","sets":["100:101:103:149"]},"author_link":["746"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：口腔がんにおけるT細胞受容体の多様性と臨床的予後因子との相関性については不明である.本研究では, 次世代シークエンサーを用いて口腔がん患者個人のNeo-antigen に反応を示していると考えられる腫瘍浸潤リンパ球におけるTCRを同定することを目的とした.原発組織と転移陽性の頸部リンパ節でいくつかの共通したクローンを持つTCR遺伝子を同定した. さらに, 同一患者内の転移陽性リンパ節は陰性リンパ節よりも多様性が高くなっていた.転移陽性リンパ節におけるTCRレパトアは, 腫瘍抗原への免疫応答を反映していることが示唆された.","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The characteristics of T cell repertoire including diversity and similarity, as well as its prognostic significance in patients with oral squamous cell carcinoma (OSCC) remain unknown. In this study, we applied a high throughput T cell receptor (TCR) sequencing method to characterize the T cell repertoires of explored the signatures of TCR repertoires in the OSCC primary tumor tissues and paired cervical lymph nodes from 16 OSCC patients, and their potential value in predicting the prognosis of patients. Our results revealed that several clonotypes uniquely detected in primary tumors which differed from paired metastatic lymph nodes. In addition, the TCR repertoire diversity in metastatic lymphatic nodes from was higher than in other non-metastatic lymph nodes. More importantly, the clonality in TCR repertoire of metastatic lymphatic node may be associated with role of the immune response to the tumor antigen, which involves in the prognosis of the patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2020(令和2)年度 科学研究費補助金 基盤研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2018-04-01 – 2021-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 本研究で得られた口腔がん患者ごとの TCR 遺伝子情報は, 抗腫瘍効果の新規遺伝子診断・治療評価法の確立へと寄与する可能性を秘めており, 個々の口腔がん患者ごとのNeo-antigenを標的とした強い免疫応答を誘導する革新的ながん免疫治療法開発の端緒となることが期待される.","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 18H03008","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18H03008/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-02"}],"displaytype":"detail","filename":"18H03008.pdf","filesize":[{"value":"838.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"18H03008","url":"https://tsurumi-u.repo.nii.ac.jp/record/987/files/18H03008.pdf"},"version_id":"5a48d016-550a-465d-a6d5-4190071b4490"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔がん","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ネオアンチゲン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱田, 良樹","creatorNameLang":"ja"},{"creatorName":"HAMADA, Yoshiki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"完全個別化医療に向けた口腔癌のネオアンチゲンの探索および宿主免疫応答の網羅的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"完全個別化医療に向けた口腔癌のネオアンチゲンの探索および宿主免疫応答の網羅的解析","subitem_title_language":"ja"},{"subitem_title":"Exploring of neoantigen and immune response in Patients with Oral Cancer","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["149"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-02"},"publish_date":"2022-03-02","publish_status":"0","recid":"987","relation_version_is_last":true,"title":["完全個別化医療に向けた口腔癌のネオアンチゲンの探索および宿主免疫応答の網羅的解析"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-01-12T08:27:31.995633+00:00"}