{"created":"2024-08-09T05:19:10.634572+00:00","id":2000128,"links":{},"metadata":{"_buckets":{"deposit":"122e1253-d38a-48af-bb37-50e60011ec7b"},"_deposit":{"created_by":10,"id":"2000128","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000128"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000128","sets":["100:101:103:1722471874793"]},"author_link":["864"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： Candida albicans ATCC 18804、Streptococcus mutans ATCC 25175およびStreptococcus sobrinus ATCC 33478に対するプロバイオティクス候補菌Lactobacillus crispatus YIT 12319のプロバイオティクス効果を調べた結果、L.crispatus YIT 12319は、C. albicansおよびS. mutansの増殖とC.albicans、S. mutansおよびS. sobrinusのバイオフィルム形成を抑制し、これらの微生物に対してプロバイオティクス効果を示すことが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Objective: The purpose of this study was to investigate the probiotic effect of Lactobacillus crispatus on Candida albicans and mutans streptococci. Design: Competition assays were employed to examine the growth suppression effects of the probiotic candidate L. crispatus YIT 12319 against C. albicans ATCC 18804, Candida glabrata ATCC 2001, Streptococcus mutans ATCC 25175, and Streptococcus sobrinus ATCC 33478. Furthermore, the formation of the biofilm composed of L. crispatus and the other microbe was monitored using the real time cell analyzer xCELLigence. Results: L. crispatus showed a strong and moderate inhibitory effect on the growth of C. albicans and S. mutans, respectively. L. crispatus inhibited the formation and maturation of biofilm of C. albicans, S. mutans or S. sobrinus. Conclusions: L. crispatus YIT 12319 was suggested to demonstrate the probiotic effect on C. albicans, S. mutans, and S. sobrinus.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2022(令和4)年度 科学研究費補助金 若手研究 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2020-04-01 – 2023-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔細菌学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 近年、欧米諸国や日本を含む先進国諸国では医療の発展に伴い強い感染力を有する細菌由来の感染症は減少した。一方で高齢者や周術期の患者など免疫力が減弱した宿主への日和見感染症が問題になっている。世界に目を向ければ、COVID-19 患者の日和見感染が増加しているとの報告が増えている。重度COVID-19 患者の合併症として真菌感染症が増加しており、真菌のカンジダ属に関する基礎と臨床研究が再燃している。本研究ではプロバイオティクス候補菌を用いてカンジダ属やう蝕原性細菌のバイオフィルム形成と増殖を抑制する事に成功している。これを応用することで薬に頼らない治療法や予防の一助となる事が期待できる。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 20K18815","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K18815/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"20K18815.pdf","filesize":[{"value":"220.6 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"20K18815","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000128/files/20K18815.pdf"},"version_id":"23b1ddda-1f2e-4046-9178-b74fee730c7a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Probiotics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lactobacillus crispatus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biofilm formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Candida albicans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus mutans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus sobrinus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SOGABE, Kaoru","creatorNameLang":"en"},{"creatorName":"曽我部, 薫","creatorNameLang":"ja"},{"creatorName":"ソガベ, カオル","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"SOGABE","familyNameLang":"en"},{"familyName":"曽我部","familyNameLang":"ja"},{"familyName":"ソガベ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kaoru","givenNameLang":"en"},{"givenName":"薫","givenNameLang":"ja"},{"givenName":"カオル","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"864","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40758489","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40758489"},{"nameIdentifier":"864","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"う蝕原性細菌とカンジダ属の相互作用に及ぼすプロバイオティクス候補菌の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"う蝕原性細菌とカンジダ属の相互作用に及ぼすプロバイオティクス候補菌の影響","subitem_title_language":"ja"},{"subitem_title":"Effects of the oral probiotic candidate Lactobacillus crispatus YIT 12319 on Candida albicans biofilm formation","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471874793"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000128","relation_version_is_last":true,"title":["う蝕原性細菌とカンジダ属の相互作用に及ぼすプロバイオティクス候補菌の影響"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-02T07:54:04.986533+00:00"}