{"created":"2024-08-09T05:19:07.895903+00:00","id":2000127,"links":{},"metadata":{"_buckets":{"deposit":"dfde34ba-14fb-4af4-8ac9-7baa8bec7190"},"_deposit":{"created_by":10,"id":"2000127","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000127"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000127","sets":["100:101:103:1722471874793"]},"author_link":["800"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 本研究では、口腔疾患が臨床で最も頻繁に認められる不整脈である心房細動（atrilal fibrillation: AF）に与える影響を、我々が最近構築した口腔疾患マウスモデルを用いて解析した。咬合不調和は交感神経系の慢性的活性化により心房組織のリモデリングやAF脆弱性の亢進を引き起こすことが明らかとなった。一方、cAMP標的分子Epac1の遺伝子欠損マウスでは野生型マウスと比較して咬合不調和による急性期での心機能低下、および死亡率の増加を認めた。このことから、咬合不調和はEpac1が仲介するシグナル伝達により心臓の恒常性に影響を及ぼすことが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The aim of this study was to clarify the relationship between oral diseases and atrial fibrillation (AF), one of the most prevalent arrhythmias, using mouse model of oral disease. Occlusal disharmony, which is caused by increasing the vertical height of occlusion by 0.7 mm for 2 weeks, induced the remodeling of atrial tissue, and increased the susceptibility to AF by chronic activation of sympathetic nervous system. In acute phase after occlusal disharmony induction, there was a significant decrease of cardiac function and an increase of early mortality in Epac (exchanged protein directly activated by cAMP)1-knockout mice as compared to wild-type mice. This result suggested that occlusal disharmony may affect the cardiac homeostasis via Epac1-mediated signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2022(令和4)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2020-04-01 – 2023-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：生理学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 近年、AFのリスクファクターとして知られる高血圧、糖尿病、肥満、睡眠障害などの症状を緩和することがAF治療戦略の重要な柱の１つと考えらえている（Circulation 136, 583-596, 2017）。本研究によりAF予防法ならびに治療法としての口腔保健の重要性がさらに明確になり、国民健康寿命の延伸を目的とした歯科検診や診療の推進運動に貢献できるものと期待される。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 20K10305","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K10305/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"20K10305.pdf","filesize":[{"value":"144.0 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"20K10305","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000127/files/20K10305.pdf"},"version_id":"c92d4651-1b35-4b04-af6c-23479fe5d4d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心房細動","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"cAMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epac","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUITA, Kenji","creatorNameLang":"en"},{"creatorName":"吹田, 憲治","creatorNameLang":"ja"},{"creatorName":"スイタ, ケンジ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"SUITA","familyNameLang":"en"},{"familyName":"吹田","familyNameLang":"ja"},{"familyName":"スイタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kenji","givenNameLang":"en"},{"givenName":"憲治","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"800","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90569542","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90569542"},{"nameIdentifier":"800","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"cAMP標的分子Epacを介した口腔疾患による心房細動発症機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"cAMP標的分子Epacを介した口腔疾患による心房細動発症機構の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of the pathogenesis of atrial fibrillation induced by oral disease via a cAMP target molecule Epac","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471874793"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000127","relation_version_is_last":true,"title":["cAMP標的分子Epacを介した口腔疾患による心房細動発症機構の解析"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-02T07:54:00.739326+00:00"}