{"created":"2024-08-09T05:19:04.790575+00:00","id":2000125,"links":{},"metadata":{"_buckets":{"deposit":"4b800989-2c8d-4a56-8bfc-be83a960deae"},"_deposit":{"created_by":10,"id":"2000125","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000125"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000125","sets":["100:101:103:1722471874793"]},"author_link":["859"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 本研究は唾液中エクソソームを解析することで口腔扁平苔癬の病態解明および診断を目指すものである。唾液中エクソソームの回収には従来の方法よりも簡便で短時間で安定して回収可能な方法を確立した。唾液の不純物除去後、限外濾過し、サイズ排除クロマトグラフィーを応用した方法である。本法により得られた粒子がエクソソームを十分に含んでいることが確認できた。この方法を用いて健常者と口腔扁平苔癬患者の唾液を対象にさらなる検討を進めている。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：This study aims to elucidate the pathology and diagnosis of oral lichen planus by analyzing exosomes in saliva. We have established a method that is simpler than the conventional method and can be stably collected in a short time for the collection of salivary exosomes. In this method, impurities are removed from saliva, ultrafiltration is performed, and size exclusion chromatography is applied. Using this method, we are conducting further studies on the saliva of healthy subjects and patients with oral lichen planus.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2022(令和4)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2020-04-01 – 2023-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：外科系歯学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 本研究はOLPの病態に、これまでに考えられていなかったエクソソームによる細胞間情報伝達が関連している可能性に着目した。その関与を明らかにすることで、新たな診断法を確立するとともに、さらにエクソソームの特徴を利用した新たな治療法の開発につなげることを目指した研究である。本研究が新たな診断・治療法確立の一助となれば、OLP患者のQOLの維持・向上に大きく貢献しうると考えられる。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 20K10104","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K10104/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"20K10104.pdf","filesize":[{"value":"887.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"20K10104","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000125/files/20K10104.pdf"},"version_id":"adba7f51-35a7-48b0-ba34-faa6527c3a47"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔扁平苔癬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"OLP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"エクソソーム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TOYODA, Nagataka","creatorNameLang":"en"},{"creatorName":"豊田, 長隆","creatorNameLang":"ja"},{"creatorName":"トヨダ, ナガタカ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"TOYODA","familyNameLang":"en"},{"familyName":"豊田","familyNameLang":"ja"},{"familyName":"トヨダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Nagataka","givenNameLang":"en"},{"givenName":"長隆","givenNameLang":"ja"},{"givenName":"ナガタカ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"859","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80257344","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80257344"},{"nameIdentifier":"859","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"エクソソーム内物質に着目した口腔扁平苔癬の病因・病態解明と新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エクソソーム内物質に着目した口腔扁平苔癬の病因・病態解明と新規治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Elucidation of etiology and pathology of oral lichen planus focusing on exosomes and development of novel treatment","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471874793"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000125","relation_version_is_last":true,"title":["エクソソーム内物質に着目した口腔扁平苔癬の病因・病態解明と新規治療法の開発"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-02T07:53:52.514947+00:00"}