{"created":"2024-08-09T05:19:01.585879+00:00","id":2000122,"links":{},"metadata":{"_buckets":{"deposit":"2eea740e-4e8c-4291-b8e1-e12d8af40cb1"},"_deposit":{"created_by":10,"id":"2000122","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000122"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000122","sets":["100:101:103:1722471874793"]},"author_link":["773"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： ジルコニアインプラントの軟組織付着能の向上を目指して，まず，ジルコニアへの二段階タンパク質吸着についてQCM法を用いて解析し，タンパク質吸着はその順番が影響することを見出した．さらに，フィブロネクチンを固定化したジルコニアインプラントの動物埋入実験を行い，インプラント付着軟組織において，インプラント体に垂直に配向しているコラーゲン線維が確認できた．本研究の結果から，フィブロネクチン固定化は軟組織付着能の向上に効果があることが結論できる．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：First, two-step protein adsorption was analyzed by using QCM method to improve the soft tissue attachment on zirconia implant. It revealed than the order of protein adsorption influence the following protein adsorption. Next, we did the animal implantation experiments of fibronectin adsorbed zirconia implants. Perpendicularly oriented collage fibers towards zirconia implants were observed in the attached soft tissue. It concluded that fibronectin immobilization was effected to improve the soft tissue attachment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2022(令和4)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2020-04-01 – 2023-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：歯科理工学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義：近年，歯科用インプラントとして，ジルコニアが注目を集めている．本研究では，生体内を模倣した二段階吸着を解析することによって，ジルコニアへのタンパク質に関する新たな知見を得ることができた．また，我々が開発したトレシルクロリド法を用いることによって，ジルコニアに細胞接着タンパク質を固定することができた．軟組織付着能の向上だけではなく，生体反応を制御できる生理活性物質固定化ジルコニアインプラント創製の可能性が期待できる．","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 20K10021","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K10021/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"20K10021.pdf","filesize":[{"value":"667.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"20K10021","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000122/files/20K10021.pdf"},"version_id":"00817d22-6d3a-4bfe-8710-9b0df37883fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"トレシルクロリド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ジルコニア","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Y-TZP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞接着タンパク質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"フィブロネクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"軟組織付着","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"QCM","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HAYAKAWA, Tohru","creatorNameLang":"en"},{"creatorName":"早川, 徹","creatorNameLang":"ja"},{"creatorName":"ハヤカワ, トオル","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"HAYAKAWA","familyNameLang":"en"},{"familyName":"早川","familyNameLang":"ja"},{"familyName":"ハヤカワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tohru","givenNameLang":"en"},{"givenName":"徹","givenNameLang":"ja"},{"givenName":"トオル","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"773","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40172994","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40172994"},{"nameIdentifier":"773","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"タンパク質固定化により軟組織付着の獲得を目指したジルコニアインプラントの創製","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"タンパク質固定化により軟組織付着の獲得を目指したジルコニアインプラントの創製","subitem_title_language":"ja"},{"subitem_title":"Invention of zirconia implant which has a tight attachment towards soft tissue by means of protein immobilization","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471874793"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000122","relation_version_is_last":true,"title":["タンパク質固定化により軟組織付着の獲得を目指したジルコニアインプラントの創製"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-02T07:53:39.192699+00:00"}