{"created":"2024-08-09T05:18:59.019084+00:00","id":2000121,"links":{},"metadata":{"_buckets":{"deposit":"a4c0d9ce-101e-4d64-930b-94384ed5854f"},"_deposit":{"created_by":10,"id":"2000121","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000121"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000121","sets":["100:101:103:1722471874793"]},"author_link":["824"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Epsten-Barrウイルス (EBウイルス) 再活性化因子BZFL1プロモーター領域下流にルシフェラーゼを連結した遺伝子を導入したTgマウスを用いて、女性ホルモン低下がEBウイルスの再活性化を引き起こすかを検討した。卵巣摘出（OVX）処置を施す週齢や処置後の観察期間などの検討を繰り返したところ、10週齢までにOVX処置をして10週以降で唾液分泌量の有意な低下と唾液中のαアミラーゼ活性の低下の低下傾向、および唾液腺組織でのBZFL1プロモーター活性の増加傾向を認めた。このことから、エストロゲン量の低下、あるいは低下に伴う生体の恒常性の変化によりEBウイルスが再活性化しうる可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：We previousry estabilised transgenic mice with a luciferase gene linked downstream of the promoter region of BZFL1, an Epstein-Barr virus (EB virus) reactivation factor. This study was conducted to determine whether the reduction of female hormones by ovariectomy (OVX) causes EB virus reactivation. Examinations were repeated at various ages, such as weeks of OVX treatment and observation period after OVX treatment. Resulted significant decrease in salivary secretion and a decreasing trend of α-amylase activity in saliva and an increasing trend of BZFL1 promoter activity in salivary gland tissues were observed after 10 weeks of OVX treatment. This suggests that the EB virus may be reactivated by a decrease in estrogen levels or by changes in homeostasis of the body associated with a decrease in estrogen levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2022(令和4)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2020-04-01 – 2023-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：分子病理学　病態生化学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : シェーグレン症候群は本邦ではおよそ50万人の患者が想定されている。本症では、唾液腺の組織障害を起因とした口腔乾燥症により食事が困難となり、口腔内の疼痛、味覚障害、歯周病のリスク、口臭などから日常生活のQOLを著しく低下するほか、約３割の患者には間質性肺炎・腎炎・中枢神経障害など重度の臓器傷害を発症し、一部は悪性リンパ腫などの腫瘍性疾患に進展する疾患である。本研究課題の遂行により得られた成果は、中高年の女性に発症することの多い難病である本症についてその病態成立機序解明の一助となりうる。これは、高齢化社会において女性が長く健康で社会で活躍するために重要であり、社会的意義も大きいと考えられる。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 20K09928","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K09928/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"20K09928.pdf","filesize":[{"value":"292.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"20K09928","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000121/files/20K09928.pdf"},"version_id":"6d51745a-bd90-4a81-9594-a547167058a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"EBウイルス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シェーグレン症候群","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エストロゲン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液分泌障害","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAYAMA, Ryoko","creatorNameLang":"en"},{"creatorName":"中山, 亮子","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, リョウコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"NAKAYAMA","familyNameLang":"en"},{"familyName":"中山","familyNameLang":"ja"},{"familyName":"ナカヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ryoko","givenNameLang":"en"},{"givenName":"亮子","givenNameLang":"ja"},{"givenName":"リョウコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"824","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50749843","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50749843"},{"nameIdentifier":"824","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"EBウイルス遺伝子導入マウスによるシェーグレン症候群発症機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EBウイルス遺伝子導入マウスによるシェーグレン症候群発症機構の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the mechanism of Sjogren's syndrome pathogenesis by EBV reactivation promoter gene transgenic mice","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471874793"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000121","relation_version_is_last":true,"title":["EBウイルス遺伝子導入マウスによるシェーグレン症候群発症機構の解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-02T07:53:35.114632+00:00"}