{"created":"2024-08-09T05:18:58.806778+00:00","id":2000120,"links":{},"metadata":{"_buckets":{"deposit":"2577aa5e-80a6-4135-a1bb-026a3477af34"},"_deposit":{"created_by":10,"id":"2000120","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000120"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000120","sets":["100:101:103:1722471874793"]},"author_link":["810"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Handling stressによって，青斑核と前頭前野，背側縫線核と扁桃体基底核外側のモノアミン神経活動が亢進した．ミダゾラムとNBI127914の局所投与は，ストレス状況下のこれらの神経活動の亢進を抑制するのに対し，デクスメデトミジンは，ストレス状況下のこれらの神経系の活動の亢進を抑制しなかった．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Handing stress enhanced monoaminergic activity in the locus coeruleus and the prefrontal cortex, dorsal raphe nucleus and amygdala. Local infusion of midazolam and NBI127914 inhibited the enhanced of these neural activity under stress conditions, whereas dexmedetomidine did not inhibit the enhanced.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2022(令和4)年度 科学研究費補助金 若手研究 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2019-04-01 – 2023-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：静脈内鎮静法","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 歯科治療はストレスを引き起こすストレッサーとなりうる ．歯科麻酔臨床では，ストレス軽減に静脈内鎮静法が有効である．しかしながら，現在静脈内鎮静法を行う機会が増えているが，脳内複数部位のモノアミン神経系活動の中枢神経系作用発現機構の検討はほとんど行われていない．本研究では、静脈内鎮静法薬の中枢神経作用機構を明らかすることで歯科医療の安全性の向上を図ることができる.","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 19K19215","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K19215/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"19K19215.pdf","filesize":[{"value":"96.0 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"19K19215","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000120/files/19K19215.pdf"},"version_id":"f0e22327-73f2-4be3-86b4-14f30f6981c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"microdialysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ADHD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress handling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMADA, Makiko","creatorNameLang":"en"},{"creatorName":"山田, 麻記子","creatorNameLang":"ja"},{"creatorName":"ヤマダ, マキコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"YAMADA","familyNameLang":"en"},{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Makiko","givenNameLang":"en"},{"givenName":"麻記子","givenNameLang":"ja"},{"givenName":"マキコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"810","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20556526","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20556526"},{"nameIdentifier":"810","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"注意欠如・多動性症への静脈内鎮静法の安全性の検証と新たな全身管理法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"注意欠如・多動性症への静脈内鎮静法の安全性の検証と新たな全身管理法の開発","subitem_title_language":"ja"},{"subitem_title":"Verification of the safety of intravenous sedation for attention-deficit/hyperactivity disorder and development of a new systemic management method","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471874793"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000120","relation_version_is_last":true,"title":["注意欠如・多動性症への静脈内鎮静法の安全性の検証と新たな全身管理法の開発"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-02T07:53:31.302640+00:00"}