{"created":"2024-08-07T08:31:15.698897+00:00","id":2000113,"links":{},"metadata":{"_buckets":{"deposit":"c5cd6cfe-eb1a-4d2a-989a-146cfd673046"},"_deposit":{"created_by":10,"id":"2000113","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000113"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000113","sets":["100:101:103:1722471628261"]},"author_link":["799"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 炎症性腸疾患寛解期（IBD）の患者と健常者を対象に3DSを含む専門的口腔ケアを介入項目として臨床試験を行った。介入前後で口腔内から唾液、歯面プラーク、舌苔、および糞便サンプルを採取した。評価項目は、歯周組織検査、唾液・糞便カルプロテクチン量、口腔・腸内細菌叢の解析とした。介入後は上記評価項目において改善がみられたケースが多かった。以上より、唾液カルプロテクチンは、IBDの病態把握マーカーの候補として可能性を有することがわかった。また専門的口腔ケアは、口腔と腸内環境を健常化に寄与することが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：A chronic immune-mediated inflammatory disease of the gastrointestinal tract known as inflammatory bowel disease (IBD) is being widely investigated with growing attention for possible involvement of oral pathogens. This study focused on the effects of a progressive oral-health care on the conditions of IBD patients in remission comparing with healthy volunteers. In addition, salivary calprotectin; a calcium-binding antimicrobial protein complex was targeted aiming to assess the inflammatory activity in IBD patients to monitor disease activity as a biomarker instead of fecal calprotectin. It was indicated that a progressive oral-health management including self-oral care using a custom-tray and hypochlorous acid electrolyzed water (twice a day) contributes to the improvement of the oral environment of IBD patients in remission. Salivary calprotectin might be a useful marker for monitoring IBD disease state.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2021(令和3)年度 科学研究費補助金 若手研究 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2019-04-01 – 2022-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：社会歯学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 炎症性腸疾患（IBD）は、再燃と寛解を繰り返す病態であるため、寛解期が長く続けば患者の生活の質は上がり、負担も大きく軽減される。そのためには継続的な病態把握が可能なマーカーの探索は必要不可欠である。本研究で採用した唾液カルプロテクチンはすでに保険収載されている便中カルプロテクチンと同様の傾向を示した。得られた知見は、今後のIBDバイオマーカ―を対象とした臨床研究に寄与することが考えられる。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 19K19339","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K19339/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"19K19339.pdf","filesize":[{"value":"171.2 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"19K19339","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000113/files/19K19339.pdf"},"version_id":"6d5b991a-8fce-40ce-abe2-e9e9f3fe02e6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"炎症性腸疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔保健管理","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"次世代シークエンス解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液カルプロテクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ELISA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OTSUKA, Ryoko","creatorNameLang":"en"},{"creatorName":"大塚, 良子","creatorNameLang":"ja"},{"creatorName":"オオツカ, リョウコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OTSUKA","familyNameLang":"en"},{"familyName":"大塚","familyNameLang":"ja"},{"familyName":"オオツカ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ryoko","givenNameLang":"en"},{"givenName":"良子","givenNameLang":"ja"},{"givenName":"リョウコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"799","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00803701","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00803701"},{"nameIdentifier":"799","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性腸疾患患者の寛解期維持に寄与する口腔保健管理についての臨床研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性腸疾患患者の寛解期維持に寄与する口腔保健管理についての臨床研究","subitem_title_language":"ja"},{"subitem_title":"Clinical study on oral-health management in sustaining the condition of inflammatory bowel disease patients in remission","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471628261"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000113","relation_version_is_last":true,"title":["炎症性腸疾患患者の寛解期維持に寄与する口腔保健管理についての臨床研究"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-03T00:48:33.287549+00:00"}