{"created":"2024-08-07T08:31:12.632060+00:00","id":2000110,"links":{},"metadata":{"_buckets":{"deposit":"08522c89-6b28-41b3-8871-d6bc7677961a"},"_deposit":{"created_by":10,"id":"2000110","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000110"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000110","sets":["100:101:103:1722471628261"]},"author_link":["950"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 咬合不調和は交感神経活動を増加させ、心機能の恒常性を阻害することが報告されている。また、レニンアンジオテンシン系（RAS）阻害剤であるカプトプリル（Cpt）は、心臓リモデリングに対する抑制効果をもつ有用な心不全治療薬である。本研究では、歯科用レジンをマウスの下顎切歯に装着したマウスモデル(Bite-opening; BO)を用いて「Cptは咬合不調和により誘発される心筋のアポトーシスを予防する」という仮説をたて、その検証を試みた。その結果、BOによる心筋のアポトーシスはRASの活性化を介して誘発される可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Occlusal disharmony has been suggested to increase sympathetic nerve activity and increase the onset of cardiac dysfunction. On the other hand, renin-angiotensin system (RAS) inhibitor captopril (Cpt) is most effective for preventing cardiac remodeling in patients with heart failure. This research thus hypothesized that Cpt might prevent cardiac dysfunction induced by occlusal disharmony using a bite-opening (BO) mouse model which was developed by cementing a suitable appliance onto the mandibular incisor. In Masson trichrome staining, the rate of fibrosis was significantly increased in the BO group, and its effect was suppressed in the BO + Cpt group. The rate of apoptosis in TUNEL staining was also significantly increased in the BO group, and its effect was suppressed in the BO + Cpt group. These results suggest that BO-mediated stress might induce cardiac apoptosis through the activation of RAS.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2021(令和3)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2019-08-30 – 2022-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：生理学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 咬合不調和は交感神経活動を増加させ、心機能の恒常性を阻害することが報告されている。また、レニンアンジオテンシン系（RAS）阻害剤であるカプトプリル（Cpt）は、心臓リモデリングに対する抑制効果をもつ有用な心不全治療薬である。本研究では、咬合異常が全身に与える影響を調べた。咬合異常による心筋の細胞死はRASの活性化を介して誘発される可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 19K24109","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K24109/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"19K24109.pdf","filesize":[{"value":"182.7 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"19K24109","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000110/files/19K24109.pdf"},"version_id":"9c73518a-9a72-43e9-a41d-b00b639938df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"フレイル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ITO, Aiko","creatorNameLang":"en"},{"creatorName":"伊藤, 愛子","creatorNameLang":"ja"},{"creatorName":"イトウ, アイコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"ITO","familyNameLang":"en"},{"familyName":"伊藤","familyNameLang":"ja"},{"familyName":"イトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Aiko","givenNameLang":"en"},{"givenName":"愛子","givenNameLang":"ja"},{"givenName":"アイコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"950","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70846401","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70846401"},{"nameIdentifier":"950","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔疾患は心筋・骨格筋フレイルに関与するか?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔疾患は心筋・骨格筋フレイルに関与するか?","subitem_title_language":"ja"},{"subitem_title":"Does oral disease contribute to cardiac and skeletal muscle frailty?","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471628261"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000110","relation_version_is_last":true,"title":["口腔疾患は心筋・骨格筋フレイルに関与するか?"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-03T00:48:21.682749+00:00"}