{"created":"2024-08-07T07:25:36.073568+00:00","id":2000104,"links":{},"metadata":{"_buckets":{"deposit":"e660d0bb-8ad4-4ced-9da5-b4efbf91fc13"},"_deposit":{"created_by":10,"id":"2000104","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000104"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:02000104","sets":["100:101:103:1722471628261"]},"author_link":["904"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：C57BL/6/Jマウスを用いて、Control群、Porphulomonas gingivalis 由来LPS(PG-LPS)群、TLR４シグナル阻害薬（TAK-242）投与群、LPS+TAK群を作成した。PG-LPS投与群の心機能は有意に低値、RIP3・NOX4の発現量は有意に増加、心臓線維化領域は増加、筋小胞体でCa2+調節に重要なホスホランバン、リアノジン受容体のリン酸化は有意に増加した。PG-LPS群で確認されたこれらの心機能障害はTLR4シグナル阻害薬（TAK-242）の併用投与により保護された。PG-LPSは、TLR4シグナルを介して心機能障害を誘導していることを示唆している","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Lipopolysaccharide (LPS) is well known to activate Toll-like receptor 4 (TLR4) signaling and induce cardiac dysfunctions. The aim of the present study was to investigate the effects of LPS derived from Porphylomonas gingivalis (PG-LPS) on cardiac function in mice with or without an inhibitor of TLR4 signaling (TAK-242) for 4 weeks. Mice were divided into 4 groups:1) Control 2) PG-LPS-treated group, 3) TAK-242-treated group, and 4) PG LPS+TAK-treated groups. We first examined cardiac function by echocardiography and found that cardiac function was significantly decreased by the treatment of PG-LPS, but TAK-242 protected the dysfunction. Cardiac fibrosis (Masson-trichrome staining) and myocyte apoptosis (TUNEL staining) were significantly increased by the treatment of PG-LPS, but TAK-242 blocked these changes. These data suggest that chronic PG-LPS infusion might play an important role for the development of cardiac dysfunction via activation of TLR4 signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2021(令和3)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2018-04-01 – 2022-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：生理学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 歯周病と心疾患の関連性については、疫学的に関連があるという報告は多いが、一方で最近米国心臓病協会(AHA)より、因果関係について断定できる確証はないことが報告された (Lockhart PB et al. Circulation 2021)。本研究より歯周病の罹患を予防することは、健康寿命の延伸に重要であることが理解されれば、欧米諸国に比較して低い我国の歯科検診受診率は向上し(スウェーデン90%,アメリカ 80%,イギリス 70%, 日本6%)、日本歯科医師会と厚生労働省が推進する8020運動(80歳以上でも自分の歯を20本以上保つことで豊かな人生を)の達成率増加にも貢献すると期待される。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 18K06862","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K06862/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-08-26"}],"displaytype":"detail","filename":"18K06862.pdf","filesize":[{"value":"240.4 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"18K06862","url":"https://tsurumi-u.repo.nii.ac.jp/record/2000104/files/18K06862.pdf"},"version_id":"5eec5dea-540b-4f7d-86af-84ddff191fee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"線維化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内伝達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OKUMURA, Satoshi","creatorNameLang":"en"},{"creatorName":"奥村, 敏","creatorNameLang":"ja"},{"creatorName":"オクムラ, サトシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OKUMURA","familyNameLang":"en"},{"familyName":"奥村","familyNameLang":"ja"},{"familyName":"オクムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Satoshi","givenNameLang":"en"},{"givenName":"敏","givenNameLang":"ja"},{"givenName":"サトシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"904","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60233475","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60233475"},{"nameIdentifier":"904","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"歯周病による心疾患発症メカニズムとEpac1の治療標的としての可能性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯周病による心疾患発症メカニズムとEpac1の治療標的としての可能性","subitem_title_language":"ja"},{"subitem_title":"Mechanism of cardiac disease induced by periodontal disease and its therapeutic target of Epac1","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["1722471628261"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-26"},"publish_date":"2024-08-26","publish_status":"0","recid":"2000104","relation_version_is_last":true,"title":["歯周病による心疾患発症メカニズムとEpac1の治療標的としての可能性"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-09-03T00:47:56.725898+00:00"}