{"created":"2023-05-15T08:56:03.565297+00:00","id":1312,"links":{},"metadata":{"_buckets":{"deposit":"b020281d-09be-410e-a059-3c60fb6dce05"},"_deposit":{"created_by":10,"id":"1312","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1312"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001312","sets":["100:101:103:189"]},"author_link":["909"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究の目的は高齲蝕感受性と低齲蝕感受性を有する患児におけるKCNJ12とSTIM1遺伝子のSNPsのスクリーンをすることであった。我々はKCNJ12とSTIM1遺伝子のSNPsが齲蝕感受性遺伝子と関連があるか調査した。被験者は5～6歳の小児計103人とした。S. mutans(-)グループではchi-square検定によりKCNJ12のrs4985866 SNPと齲蝕感受性の有意な関連が認められた。この研究からSTIM1のrs3813880 SNPとrs3750996 SNPにおいては齲蝕感受性と関連が認められず、KCNJ12のrs4985866 SNPは齲蝕感受性にかかわる可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The objective of this study was to screen for single nucleotide polymorphisms (SNPs) in genes coding KCNJ12 and STIM1, in patients with severs caries and in low caries susceptibility individuals. We investigated whether SNPs in both KCNJ12 and STIM1 genes are associated with the caries susceptibility. Cases were 103 children ages 5-6 yrs. Statistical analysis based on Chi-square test revealed a significant association of the rs4985866 SNP of KCNJ12 with susceptibility to caries in low-S.mutans group. Within the limitations of this study, rs3813880 SNP and rs3750996 SNP of STIM1 seem to be negatively associated, while rs4985866 SNP of KCNJ12 is associated with caries susceptibility.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2011(平成23)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2010 – 2011","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 22792071","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22792071/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-18"}],"displaytype":"detail","filename":"22792071.pdf","filesize":[{"value":"296.7 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"22792071","url":"https://tsurumi-u.repo.nii.ac.jp/record/1312/files/22792071.pdf"},"version_id":"14dd131c-b2f4-485a-9dfe-d57c59fdb908"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"齲蝕感受性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"SNPs 解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"生活習慣病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子検査","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"OHTA, Masumi","creatorNameLang":"en"},{"creatorName":"太田, 増美","creatorNameLang":"ja"},{"creatorName":"オオタ, マスミ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OHTA","familyNameLang":"en"},{"familyName":"太田","familyNameLang":"ja"},{"familyName":"オオタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Masumi","givenNameLang":"en"},{"givenName":"増美","givenNameLang":"ja"},{"givenName":"マスミ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"909","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40410047","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40410047"},{"nameIdentifier":"909","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"齲蝕発症リスク評価法の確立と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"齲蝕発症リスク評価法の確立と臨床応用","subitem_title_language":"ja"},{"subitem_title":"The establishment of diagnostic method for caries risk and the clinical application","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["189"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-18"},"publish_date":"2022-05-18","publish_status":"0","recid":"1312","relation_version_is_last":true,"title":["齲蝕発症リスク評価法の確立と臨床応用"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T04:48:48.349661+00:00"}