{"created":"2023-05-15T08:56:03.309884+00:00","id":1308,"links":{},"metadata":{"_buckets":{"deposit":"85fa0dc8-0f5c-40eb-9acc-19c3c0e91151"},"_deposit":{"created_by":10,"id":"1308","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1308"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001308","sets":["100:101:103:189"]},"author_link":["925"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究ではGRINファミリーの遺伝子機能を明らかにするために、GRIN3遺伝子の機能解析を行った。GRIN3がドーパミンD2受容体を介したシグナル伝達を増強すること、D2受容体量を増加させることを明らかにした。また、GRIN3がGRK2およびGRK6と結合することを明らかにし、そのメカニズムはGRIN3がGoと結合することにより、GRK2およびGRK6とGRIN3間の結合も強くなるという全く新規のものであった。GRIN3はGRKよるD2受容体の脱感作機能を阻害すると考えられた。また、GRIN3 KOマウスにおいて活動量の低下と著しい不安様行動を示すこと、ドーパミントランスポーター阻害剤に対する反応性が異なる点を明らかとした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：We examined molecular mechanisms and in vivo functions of GRIN3 . In this study, we revealed that GRIN3 modulated both signal transduction and amounts of dopamine D2 receptor. GRIN3 was able to bind to not only Galpha(o) but also GRK family. Especially, GRIN3 binding with GRK6 was greatly enhanced in a manner of Galpha(o) binding to GRIN3. Probably, by this mechanism, GRIN3 trapped the crucial region of GRK2 and GRK6 for desensitization of D2 receptor, and potentiated G protein signaling. Thus, GRIN3 seems to be inhibitor of GRK family, at least GRK2 and GRK6. Finally, we observed that GRIN3 KO mice showed less locomotor activity, increased anxiety, and less sensitivity for dopamine transporter inhibitor, GBR12909.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2011(平成23)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2010 – 2011","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 22791147","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22791147/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-18"}],"displaytype":"detail","filename":"22791147.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"22791147","url":"https://tsurumi-u.repo.nii.ac.jp/record/1308/files/22791147.pdf"},"version_id":"1e2fca37-8f03-43d5-8a87-93a8de181170"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"精神薬理学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"GRIN3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Go","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ドーパミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"D2 受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"MOTOTANI, Yasumasa","creatorNameLang":"en"},{"creatorName":"本谷, 安正","creatorNameLang":"ja"},{"creatorName":"モトタニ, ヤスマサ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"MOTOTANI","familyNameLang":"en"},{"familyName":"本谷","familyNameLang":"ja"},{"familyName":"モトタニ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasumasa","givenNameLang":"en"},{"givenName":"安正","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"925","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60421830","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60421830"},{"nameIdentifier":"925","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遺伝子操作動物を用いたGRINの脳機能解明および脳形成に関与するGPCRの同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝子操作動物を用いたGRINの脳機能解明および脳形成に関与するGPCRの同定","subitem_title_language":"ja"},{"subitem_title":"Elucidation of molecular mechanisms and in vivo functions of GRIN3 for dopamine D2 receptor","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["189"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-18"},"publish_date":"2022-05-18","publish_status":"0","recid":"1308","relation_version_is_last":true,"title":["遺伝子操作動物を用いたGRINの脳機能解明および脳形成に関与するGPCRの同定"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T06:10:18.655454+00:00"}