{"created":"2023-05-15T08:56:01.901937+00:00","id":1283,"links":{},"metadata":{"_buckets":{"deposit":"419ffa48-fcdb-4459-96bf-42986fa225d7"},"_deposit":{"created_by":10,"id":"1283","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1283"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001283","sets":["100:101:103:186"]},"author_link":["885"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：骨吸収抑制薬bisphosphonate(BP)は,その強い骨吸収抑制作用により骨吸収亢進を伴う疾患に広く応用されているが,インフルエンザ様の炎症反応や消化管傷害などの副作用がある.イオントフォレシス(IOP)は電場を用いて薬剤の経皮的な吸収を増加させる方法で,無痛で,消化管・肝臓での薬物代謝も少ない.本研究で,BPsのIOPによるマウスへの経皮的な投与に成功し,その効果はIOPの通電量,通電時間,BPの濃度に比例して増加する結果を得た.","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Bisphosphonates (BPs) have powerful anti– bone-resorptive effects. However, BPs are known to have several undesirable side effects (such as influenzalike fever, gastrointestinal disturbance). Iontophoresis is the one of the electrical methods that have been employed to enhance drug transportation across the skin. Transdermal drug delivery has a number of potential advantages compared with conventional methods: painless, no degradation from passage through the gastrointestinal tract or the liver. BPs were successfully transported through living mouse skin in a dose-, voltage-, and time-dependent manner.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2012(平成24)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2011 – 2012","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 23792454","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23792454/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"23792454.pdf","filesize":[{"value":"496.0 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"23792454","url":"https://tsurumi-u.repo.nii.ac.jp/record/1283/files/23792454.pdf"},"version_id":"e14a93ee-f8f4-49e9-9668-2e9df7bf5a92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ビスフォスフォネート","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マウスモデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"イオントフォレシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"顎骨壊死","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"船山, ひろみ","creatorNameLang":"ja"},{"creatorName":"FUNAYAMA, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"副作用を軽減する安全で簡便なビスフォスフォネート製剤の投与方法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"副作用を軽減する安全で簡便なビスフォスフォネート製剤の投与方法の開発","subitem_title_language":"ja"},{"subitem_title":"The development of a new route of administration to relieve the side effects of Bisphosphonates.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["186"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"1283","relation_version_is_last":true,"title":["副作用を軽減する安全で簡便なビスフォスフォネート製剤の投与方法の開発"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-02-06T05:43:24.187084+00:00"}