{"created":"2023-05-15T08:56:01.675979+00:00","id":1278,"links":{},"metadata":{"_buckets":{"deposit":"d9b1bb88-a9b5-41bf-8cf4-ee1524e7d1f6"},"_deposit":{"created_by":10,"id":"1278","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1278"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001278","sets":["100:101:103:186"]},"author_link":["770"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、アジスロマイシン(AZM)の歯肉線維芽細胞(hGFs)および歯根膜細胞(hPDLFs)に及ぼす影響について検討した。LPS刺激下において、hGFsのみでAZM濃度依存的にIL-6,IL-8,MMP-1およびTIMP-1の発現を増強させたが、hPDLFsでは変化はなかった。今回の研究により、歯肉局所においてAZMがIL-6やIL-8を増強させて炎症の改善に寄与し、かつMMP-1の遺伝子発現の増強させることで結合組織のリモデリングを促進させ、歯周ポケットの減少が生じるメカニズムが存在することが考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：We investigated the effects of AZM on human gingival fibroblasts (hGFs) and human periodontal ligament cells (hPDLFs) by measuring the expression levels of the inflammatory cytokines IL-6 and IL-8, as well as MMP-1, and TIMP-1 and which are associated with connective tissue remodeling. The mRNA expression of IL-6 and IL-8 in hGFs was upregulated by AZM dose-dependently under LPS stimulation conditions. However, hPDLFs showed no association between AZM and IL-6 or IL-8. The hGFs upregulated MMP-1 and TIMP-1 in response to AZM dose-dependently. In addition, the hPDLFs did not exhibit differences in expression of MMP-1, MMP-2, TIMP-1, or TIMP-2. We speculate that such highly concentrated AZM would be able to supress periodontal pathogenic bacteria, destroy an already formed biofilms and periodontal pocket reduction in short time period.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2012(平成24)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2010 – 2012","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 22792101","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22792101/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"22792101.pdf","filesize":[{"value":"407.1 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"22792101","url":"https://tsurumi-u.repo.nii.ac.jp/record/1278/files/22792101.pdf"},"version_id":"747b26e7-acf7-4921-aa0f-cbbeed5d77aa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞・組織","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周薬物療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"NAGANO, Takatoshi","creatorNameLang":"en"},{"creatorName":"長野, 孝俊","creatorNameLang":"ja"},{"creatorName":"ナガノ, タカトシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"NAGANO","familyNameLang":"en"},{"familyName":"長野","familyNameLang":"ja"},{"familyName":"ナガノ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Takatoshi","givenNameLang":"en"},{"givenName":"孝俊","givenNameLang":"ja"},{"givenName":"タカトシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"770","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10386914","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10386914"},{"nameIdentifier":"770","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬物によりポケットリダクションを図る新たな歯周薬物療法への展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬物によりポケットリダクションを図る新たな歯周薬物療法への展開","subitem_title_language":"ja"},{"subitem_title":"Development of a new antimicrobial agent therapy to plan periodontal pocket reduction","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["186"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"1278","relation_version_is_last":true,"title":["薬物によりポケットリダクションを図る新たな歯周薬物療法への展開"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:37:22.274290+00:00"}