{"created":"2023-05-15T08:56:01.492679+00:00","id":1274,"links":{},"metadata":{"_buckets":{"deposit":"dc94fecb-0a3b-417c-bda8-6de387dec59b"},"_deposit":{"created_by":10,"id":"1274","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1274"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001274","sets":["100:101:103:186"]},"author_link":["836"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：口臭の原因物質である硫化水素は口腔癌細胞株Ca9-22細胞にアポトーシスを誘導するとともに、pleckstrinhomology-likedomain,familyA,member1(PHLDA1)の発現を上昇させた。このPHLDA1の発現上昇はアポトーシス抑制のためと推測された。また、PHLDA1を発現しない癌細胞株では薬剤に対するアポトーシス感受性が低く、PHLDA1がアポトーシス感受性マーカである可能性を示した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Ca9-22 cells that highly express pleckstrin homology-like domain, family A, member 1 (PHLDA1) are susceptible to H2S-induced apoptosis. PHLDA1 in oral cancer cells plays a role in apoptosis suppression, and PHLDA1 may be a marker of apoptosis susceptibility.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2012(平成24)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2010 – 2012","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 22592349","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22592349/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"22592349.pdf","filesize":[{"value":"376.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"22592349","url":"https://tsurumi-u.repo.nii.ac.jp/record/1274/files/22592349.pdf"},"version_id":"56d61a0f-186d-43f2-8ce9-74a3cfa3c888"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌関連遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"硫化水素","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯肉癌細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"PHLDA1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村田, 貴俊","creatorNameLang":"ja"},{"creatorName":"MURATA, Takatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔粘膜上皮細胞における癌関連遺伝子発現への口臭物質の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔粘膜上皮細胞における癌関連遺伝子発現への口臭物質の影響","subitem_title_language":"ja"},{"subitem_title":"Influence of oral malodor compounds for expression of cancer-related gene in oral epidermal cells.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["186"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"1274","relation_version_is_last":true,"title":["口腔粘膜上皮細胞における癌関連遺伝子発現への口臭物質の影響"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-02-06T05:43:25.314176+00:00"}