{"created":"2023-05-15T08:56:01.078252+00:00","id":1268,"links":{},"metadata":{"_buckets":{"deposit":"ef1f16de-51f8-41ff-a128-4123c1ada5b4"},"_deposit":{"created_by":10,"id":"1268","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1268"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001268","sets":["100:101:103:186"]},"author_link":["894"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ヒト臍帯動・静脈周囲に存在する臍帯由来間葉系細胞(以下細胞)は低侵襲で間葉系細胞を得る事ができ、新たな再生医療への応用が期待されている。本研究では細胞中より組織再生に必要不可欠であるpericyte集団を分離・培養し、その基本特性の解析、さらに石灰化誘導を確認することで組織工学的再生療法開発への可能性を検討した。CD146陽性細胞は、骨芽細胞分化誘導試薬では石灰化作用を受けなかった。さらに、その細胞集団の中にMuse細胞も認められなかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The umbilical cord-derived mesenchymal cells (hereinafter, cells) present in the vicinity of the artery and veins of the umbilical cord in humans is capable of obtaining mesenchymal cells in a low-invasive manner, and the application of such cells in the field of regenerative medicine is therefore now eagerly anticipated. In this research, the pericyte group, which is essential to tissue reproduction, was separated from the cells and then was cultured. The possibility of developing a new type of tissue engineering reproduction therapy was investigated by analyzing the basic characteristics thereof and then checking for the induction of calcification. CD146-positive cells did not calcify via the administration of osteoblast differentiation-inducing drugs. Furthermore, no Muse cells were observed in the obtained cell population.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2012(平成24)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2010 – 2012","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 22592200","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22592200/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"22592200.pdf","filesize":[{"value":"404.7 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"22592200","url":"https://tsurumi-u.repo.nii.ac.jp/record/1268/files/22592200.pdf"},"version_id":"55435570-7983-47e5-97ed-4b67aa04608d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"移植・再生医療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再生医学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞・組織","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"生理活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周組織再生材料臍帯由来間葉系細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KANAZASHI, Mikimoto","creatorNameLang":"en"},{"creatorName":"金指, 幹元","creatorNameLang":"ja"},{"creatorName":"カナザシ, ミキモト","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KANAZASHI","familyNameLang":"en"},{"familyName":"金指","familyNameLang":"ja"},{"familyName":"カナザシ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Mikimoto","givenNameLang":"en"},{"givenName":"幹元","givenNameLang":"ja"},{"givenName":"ミキモト","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"894","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80339811","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80339811"},{"nameIdentifier":"894","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"臍帯由来間葉系細胞を用いた組織工学的歯周組織再生材料の開発と臨床研究への橋渡し","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臍帯由来間葉系細胞を用いた組織工学的歯周組織再生材料の開発と臨床研究への橋渡し","subitem_title_language":"ja"},{"subitem_title":"Development of a tissue-engineering periodontal tissue-reproducing\\nmaterial using umbilical cord-derived mesenchymal cells and the association with clinical research","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["186"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"1268","relation_version_is_last":true,"title":["臍帯由来間葉系細胞を用いた組織工学的歯周組織再生材料の開発と臨床研究への橋渡し"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T03:15:24.282894+00:00"}