{"created":"2023-05-15T08:56:00.460836+00:00","id":1257,"links":{},"metadata":{"_buckets":{"deposit":"39e48af6-a90c-4a4e-a39a-8b488d9ae6e5"},"_deposit":{"created_by":10,"id":"1257","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1257"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001257","sets":["100:101:103:184"]},"author_link":["771"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、Streputococcus mutans (S. mutans) UA159のヒトβディフェンシン２(hBD2)に対する抵抗性について検討した。dlt欠失株では、hBD2の濃度依存的に生菌数が減少する傾向が認められたことから、dlt産物がペプチド耐性に寄与している可能性が示唆された。細胞表面の疎水性は、dlt欠失株で親株より低かった。ショ糖添加液体培地で培養し、試験管表面への付着とグルカン産生を検討したところ、dlt欠失株は親株より少なかった。以上のことから、電位チャージを含めた細菌表面性状とグルカン産生がS. mutans のhBD2耐性に影響している可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：In this study, resistance against human beta-defensin 2 (hBD2) in Streptococcus mutans UA159 was investigated. In the dlt operon deleted mutant but not in the parent, viable bacterial count tended to decrease by hBD2 treatment in a dose-dependent manner, suggesting that the products of dlt operon might contribute to the peptide-resistance. Cell surface hydrophobicity was lower in the dlt-deleted strain than that in the parent. When cultured in sucrose-supplemented broth, both glass surface-adhesion and the glucan production in dlt deleted strain was lesser than that in the parent. Taken together, the bacterial surface characteristics including electrostatic charge and glucan production might affect to hBD2 resistance in S. mutans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2013(平成25)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2012-04-01 – 2014-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 24792370","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24792370/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"24792370.pdf","filesize":[{"value":"623.0 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"24792370","url":"https://tsurumi-u.repo.nii.ac.jp/record/1257/files/24792370.pdf"},"version_id":"1c302906-0d0a-4605-8647-399c31912f28"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Streptococcus mutans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ディフェンシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KAKUTA, Erika","creatorNameLang":"en"},{"creatorName":"角田, 衣理加","creatorNameLang":"ja"},{"creatorName":"カクタ, エリカ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KAKUTA","familyNameLang":"en"},{"familyName":"角田","familyNameLang":"ja"},{"familyName":"カクタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Erika","givenNameLang":"en"},{"givenName":"衣理加","givenNameLang":"ja"},{"givenName":"エリカ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"771","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30585469","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30585469"},{"nameIdentifier":"771","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト口腔細菌叢構成菌の自然免疫応答による選択メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト口腔細菌叢構成菌の自然免疫応答による選択メカニズムの解明","subitem_title_language":"ja"},{"subitem_title":"The mechanism of oral flora selection by innate immunity.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["184"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-09"},"publish_date":"2022-05-09","publish_status":"0","recid":"1257","relation_version_is_last":true,"title":["ヒト口腔細菌叢構成菌の自然免疫応答による選択メカニズムの解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:39:03.958483+00:00"}