{"created":"2023-05-15T08:55:59.914759+00:00","id":1245,"links":{},"metadata":{"_buckets":{"deposit":"507ebc85-4a6a-43db-8815-2d78f92419d5"},"_deposit":{"created_by":10,"id":"1245","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1245"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001245","sets":["100:101:103:184"]},"author_link":["841"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：歯の移動初期の牽引側歯根膜における免疫系細胞の関与について形態学的、免疫組織化学的検討した。歯の移動6時間で歯根膜腔は30%以上の拡大を示し、歯根膜線維も著しく牽引されていた。免疫系細胞ではED1陽性細胞(単球、マクロファージ)の増加がみられた。MMP12の免疫組織科学所見ではED1陽性細胞ばかりでなく、多くの線維芽細胞にも反応がみられ、牽引側歯根膜では骨形成に至る前に何らかの組織防御的な反応が生じていることが明らかとなった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Tissue reaction of the tension zone of periodontal ligament ( PDL ) during orthodontic tooth movement has been simplified as tugging of PDL fibers and bone formation. However, PDL fibers in the tension zone are forced to strong tugging, which causes involvement of defense system. We examined an involvement of immune system in the tension zone of PDL in early stage of tooth movement, using histological and immunohistochemical methods. Periodontal space was enlarged to more than 130 % and the PDL fibers showed a strong tugging aspect 6 hours after initiation of tooth movement. ED1 positive cells ( macrophage and monocyte ) were increased. However, fibroblasts also showed localization of IL-1B and MMP12. This indicats that fibroblasts involve in defense reaction of the PDL, prior to rearrangement of the PDL and bone formation on the alveolar bone in the very early stage of periodontal reaction in the tension zone.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2013(平成25)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2011 – 2013","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：歯科矯正学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 23593052","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23593052/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"23593052.pdf","filesize":[{"value":"249.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"23593052","url":"https://tsurumi-u.repo.nii.ac.jp/record/1245/files/23593052.pdf"},"version_id":"cdce012d-40db-4574-962e-4f82eb39202c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯の移動","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"牽引側歯根膜","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"初期変化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫系細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"単球、マクロファージ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"NAKAMURA, Yoshiki","creatorNameLang":"en"},{"creatorName":"中村, 芳樹","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ヨシキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"NAKAMURA","familyNameLang":"en"},{"familyName":"中村","familyNameLang":"ja"},{"familyName":"ナカムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoshiki","givenNameLang":"en"},{"givenName":"芳樹","givenNameLang":"ja"},{"givenName":"ヨシキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"841","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10097321","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10097321"},{"nameIdentifier":"841","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"歯の移動初期の牽引側歯根膜に発現する免疫関連因子の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯の移動初期の牽引側歯根膜に発現する免疫関連因子の機能解析","subitem_title_language":"ja"},{"subitem_title":"Function of immunocompetent cells in the tension zone of periodontal ligament in tooth movement","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["184"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-09"},"publish_date":"2022-05-09","publish_status":"0","recid":"1245","relation_version_is_last":true,"title":["歯の移動初期の牽引側歯根膜に発現する免疫関連因子の機能解析"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T00:59:23.915944+00:00"}