{"created":"2023-05-15T08:55:59.720855+00:00","id":1242,"links":{},"metadata":{"_buckets":{"deposit":"9840f6b9-860d-488c-acc4-059763e72211"},"_deposit":{"created_by":10,"id":"1242","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1242"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001242","sets":["100:101:103:184"]},"author_link":["857"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：シスタチンはシステインプロテアーゼ・インヒビターである。システインプロテアーゼはアポトーシスに関連するため、シスタチンがアポトーシスの制御に関わっている可能性が想定される。シェーグレン症候群では唾液中のシスタチンが減少しており、とくにシスタチンSが減少していた。口唇腺においては、健常者ではシスタチンの強い染色性が認められたが、シェーグレン症候群患者では陽性例が少なく、しかもその染色性はきわめて低かった。以上の結果は、シスタチンがシェーグレン症候群の発症に関与している可能性を示唆している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The cystatins are a family of cysteine protease inhibitors. Cysteine protease inhibitors are assumed to have important roles in apoptosis. Salivary cystatin decreased in Sjogren's syndrome patients, particularly cystatin S. In the labial salivary glands, intense staining of the cystatin was observed in the normal control group, but there were few positive examples in Sjogren's syndrome patients, and the staining was extremely low. These results suggest that the cystatin participates in the regulation of onset of Sjogren's syndrome.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2013(平成25)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2011 – 2013","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 23592948","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23592948/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"23592948.pdf","filesize":[{"value":"828.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"23592948","url":"https://tsurumi-u.repo.nii.ac.jp/record/1242/files/23592948.pdf"},"version_id":"8b4e9072-80eb-4b73-a5c6-bfc8f47a41e8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シェーグレン症候群","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シスタチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液分泌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"NAKAGAWA, Yoichi","creatorNameLang":"en"},{"creatorName":"中川, 洋一","creatorNameLang":"ja"},{"creatorName":"ナカガワ, ヨウイチ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"NAKAGAWA","familyNameLang":"en"},{"familyName":"中川","familyNameLang":"ja"},{"familyName":"ナカガワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoichi","givenNameLang":"en"},{"givenName":"洋一","givenNameLang":"ja"},{"givenName":"ヨウイチ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"857","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90148057","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90148057"},{"nameIdentifier":"857","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"唾液分泌促進ならびに口腔粘膜防御へ果たすシスタチンの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"唾液分泌促進ならびに口腔粘膜防御へ果たすシスタチンの役割","subitem_title_language":"ja"},{"subitem_title":"Role of cystatin in stimulation of saliva flow and protection of oral mucosa","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["184"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-09"},"publish_date":"2022-05-09","publish_status":"0","recid":"1242","relation_version_is_last":true,"title":["唾液分泌促進ならびに口腔粘膜防御へ果たすシスタチンの役割"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T01:39:57.345951+00:00"}