{"created":"2023-05-15T08:55:59.373400+00:00","id":1236,"links":{},"metadata":{"_buckets":{"deposit":"eb947e54-9972-4907-abba-56fa386a299b"},"_deposit":{"created_by":10,"id":"1236","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1236"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001236","sets":["100:101:103:184"]},"author_link":["904"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：新規サイクリックAMP (cAMP)で活性化因子Epac の心不全発症にはたす役割を解明するため、Epac1ノックアウトマウス(Epac1KO)を作製し、イソプロテレノールの慢性投与刺激を行ったところ、Epac1KOでは心臓線維化が顕著に抑制された。そこで心臓線維化を1) 線維芽細胞内でのCollagen分子の産生 2)細胞外で成熟したCollagen分子同士の架橋によるCollagen線維の形成 3)コラーゲン分解酵素による老朽化したCollagen線維の分解の3段階に分け検討したところ3)コラーゲン分解酵素によるCollagen線維の分解亢進が主要なメカニズムであることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：In order to examine the role of Epac1 (exchange protein directly activated by cyclic AMP) on cardiac fibrosis, chronic isoproterenol (ISO) infusion (60mg/kg/day for 7 days) was performed in Epac1-null mice (Epac1KO) and wild-type controls (WT). Cardiac fibrosis was significantly inhibited in Epac1KO, compared to WT. In order to examine the mechanism, we examined the role of Epac1 in the following 3 steps : Step-1) Production of collagen fiber Step-2) Cross-linking of collagen fiber by lysyl oxidase (LOX) Step-3) Degradation of collagen fiber by matrix mettaloproteinase (MMT). Our data in this study shows that cardiac fibrosis was reduced through the inhibition of step-3.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2013(平成25)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2011 – 2013","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 23591087","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23591087/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"23591087.pdf","filesize":[{"value":"316.0 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"23591087","url":"https://tsurumi-u.repo.nii.ac.jp/record/1236/files/23591087.pdf"},"version_id":"866c4e00-ae9f-4090-b7a4-15968386e7e4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シグナル伝達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"循環器高血圧","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サイクリックAMP","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心不全","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子改変マウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"OKUMURA, Satoshi","creatorNameLang":"en"},{"creatorName":"奥村, 敏","creatorNameLang":"ja"},{"creatorName":"オクムラ, サトシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OKUMURA","familyNameLang":"en"},{"familyName":"奥村","familyNameLang":"ja"},{"familyName":"オクムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Satoshi","givenNameLang":"en"},{"givenName":"敏","givenNameLang":"ja"},{"givenName":"サトシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"904","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60233475","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60233475"},{"nameIdentifier":"904","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心臓線維化形成におけるEpacの役割と心不全治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心臓線維化形成におけるEpacの役割と心不全治療への応用","subitem_title_language":"ja"},{"subitem_title":"Role of Epac in cardiac fibrosis and its clinical application for heart failure","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["184"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-09"},"publish_date":"2022-05-09","publish_status":"0","recid":"1236","relation_version_is_last":true,"title":["心臓線維化形成におけるEpacの役割と心不全治療への応用"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T04:40:09.950505+00:00"}