{"created":"2023-05-15T08:55:59.186504+00:00","id":1233,"links":{},"metadata":{"_buckets":{"deposit":"2c4c42d4-d8f3-40b3-9684-d5a24bf4f01c"},"_deposit":{"created_by":10,"id":"1233","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1233"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001233","sets":["100:101:103:184"]},"author_link":["822"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：老齢マウスにカロリー制限を施すことで唾液腺局所でのSirtの発現ならびに活性増強を認めた。カロリー制限により、唾液分泌は増加し、酸化ストレスマーカーの８OH-dGは減少していた。また、唾液腺局所への炎症細胞浸潤は減少し、炎症性サイトカインも低値を示した。マイクロアレイの結果からは炎症・免疫関連遺伝子に加えてアミノ酸代謝関連遺伝子にも変動が認められた。発現増強が認められたセリンをマウスに摂取させたところ、投与後三週間まで唾液分泌の増加傾向が認められた。カロリー制限によりミトコンドリアの数は減少していたものの、加齢に伴うミトコンドリア変異は減少し、ミトコンドリア当たりのATP産生量も増加していた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Calorie restriction (CR) showed increase of Sirt1 expression and activity in mice salivary glands. The increased saliva secretion and the decreased 8 OH-dG, an oxidative stress marker, were confirmed. The infiltration of inflammatory cells and inflammatory cytokines were diminished. From the microarray analysis, inflammatory and immune related genes were decreased and amino acid related genes were increased. Moreover, serine revealed increased tendency saliva secretion. The number of mitochondria and the mutated mitochondria genes were decreased. However, ATP production was increased.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2013(平成25)年度 科学研究費補助金 基盤研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2011-04-01 – 2014-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 23390421","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23390421/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-09"}],"displaytype":"detail","filename":"23390421.pdf","filesize":[{"value":"623.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"23390421","url":"https://tsurumi-u.repo.nii.ac.jp/record/1233/files/23390421.pdf"},"version_id":"4d3433e4-25ab-4af2-bcd5-982285fffa98"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"唾液腺","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Sirt1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"カロリー制限","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"SAITO, Ichiro","creatorNameLang":"en"},{"creatorName":"斎藤, 一郎","creatorNameLang":"ja"},{"creatorName":"サイトウ, イチロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"SAITO","familyNameLang":"en"},{"familyName":"斎藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ichiro","givenNameLang":"en"},{"givenName":"一郎","givenNameLang":"ja"},{"givenName":"イチロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"822","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60147634","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60147634"},{"nameIdentifier":"822","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Sirt1分子による唾液分泌制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sirt1分子による唾液分泌制御機構の解明","subitem_title_language":"ja"},{"subitem_title":"Analysis of salivary secretory function via Sirt1 activation","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["184"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-09"},"publish_date":"2022-05-09","publish_status":"0","recid":"1233","relation_version_is_last":true,"title":["Sirt1分子による唾液分泌制御機構の解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T00:10:25.613697+00:00"}