{"created":"2023-05-15T08:55:58.535166+00:00","id":1220,"links":{},"metadata":{"_buckets":{"deposit":"4d89c163-0456-4630-90ac-d7ae41e0252a"},"_deposit":{"created_by":10,"id":"1220","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1220"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001220","sets":["100:101:103:181"]},"author_link":["777"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：口腔領域の再生医療成功の鍵の1つは、口腔細菌やバイオフィルムの制御である。すなわち感染制御する一方で、軟組織への影響を考慮し、さらに分化を妨げない歯科技術が必要である。機能水の1種である次亜塩素酸電解水は、強い殺菌性を示す一方で、食塩水を原料とする電解水であることから安全性が期待されている。本研究において、抗菌試験及び細胞毒性試験を行い、1) 短時間で殺菌効果を発揮、2) バイオフィルム浸透殺菌効果を有するおよび3) 硬軟組織への影響が僅かである次亜塩素酸電解水を選択し、口腔領域における再生医療への応用についてその可能性を検討した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：In oral regenerative medicine, such as clinical application of iPS cells, infection control is of the utmost importance in order to maintain the healthy oral environmental balance. In recent years, electrolyzed saline solutions are gaining interests among the medical and dental professionals for their anti-bacterial potentials in shortest possible application time. In the present study, some reactive oxygen species (ROS) based electrolyzed saline solutions containing hypochlorous acid (HClO); also known as super-oxidized water (SOW) have been examined for their anti-bacterial effects, potency of biofilm penetration and cytotoxicity. Results have indicated that SOW containing 125 (~145) mg/L active chlorine and 6.8 pH value can be effective enough to control oral pathogens. In addition, it was understood that this kind of highly purified SOW might be useful in oral regenerative medicine as it showed very low level of cytotoxicity on KB cells derived from pharyngeal mucosal epithelium.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2014(平成26)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2012-04-01 – 2015-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：社会歯学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 24792371","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24792371/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-29"}],"displaytype":"detail","filename":"24792371.pdf","filesize":[{"value":"195.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"24792371","url":"https://tsurumi-u.repo.nii.ac.jp/record/1220/files/24792371.pdf"},"version_id":"1df37321-782f-4db4-9cb4-2f11f51ee5c1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"機能水","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔再生医療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"感染制御","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞毒性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"OKADA, Ayako","creatorNameLang":"en"},{"creatorName":"岡田, 彩子","creatorNameLang":"ja"},{"creatorName":"オカダ, アヤコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OKADA","familyNameLang":"en"},{"familyName":"岡田","familyNameLang":"ja"},{"familyName":"オカダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ayako","givenNameLang":"en"},{"givenName":"彩子","givenNameLang":"ja"},{"givenName":"アヤコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"777","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60515584","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60515584"},{"nameIdentifier":"777","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"iPS細胞をより安全に臨床応用するための感染制御方法の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"iPS細胞をより安全に臨床応用するための感染制御方法の検討","subitem_title_language":"ja"},{"subitem_title":"A methodological study on infection control for safe clinical application of iPS cells","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["181"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-29"},"publish_date":"2022-04-29","publish_status":"0","recid":"1220","relation_version_is_last":true,"title":["iPS細胞をより安全に臨床応用するための感染制御方法の検討"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:49:44.133522+00:00"}