{"created":"2023-05-15T08:55:58.215009+00:00","id":1215,"links":{},"metadata":{"_buckets":{"deposit":"145cdd47-245a-4f1f-9158-93b96d5286f0"},"_deposit":{"created_by":10,"id":"1215","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1215"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001215","sets":["100:101:103:181"]},"author_link":["796"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：歯周炎患者(n=116)に対する抗菌療法を含む歯周治療により、口腔総菌数は変化せずP. gingivalis菌比率の著明な低下が確認され、蛍光insituハイブリダイゼーション(FISH)法においても、P.gingivalis菌シグナルが低下し、総レンサ球菌のシグナルが増加した。また重度歯周炎患者(n=12)の菌血症に関しては、スケーリング前で10%、直後で50%、10分後で20%が陽性であったが、歯周治療実施後はスケーリング直後でも5例中３例の菌血症が抑制できた。歯周治療による口腔細菌の制御が、口腔疾患制御は勿論歯原性菌血症、LPS血症など全身疾患のリスク低減になることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Periodontal treatments including the antibacterial therapy for periodontitis patients (n=116) resulted in the significant reduction of P. gingivalis ratio, while the number of the total bacteria did not change. The study of the fluorescence insitu hybridization (FISH) also showed that the signal of P.gingivalis decreased and the signal of total streptococci increased. In addition, peripheral blood of the severe periodontitis patients(n=12) showed that 10% were bacteremia-positive before scaling, 20% for just after scaling, and 50% for 10 minutes after scaling. While after periodontal treatment including antibacterial therapy, the periferal blood of three of five patients turned bacteremia-negative for even just after scaling. These results suggest that oral bacterial control with the periodontal treatment leads to the risk reduction of systemic disease including odontogenic bacteremia and endotoxinemia, as well as oral diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2014(平成26)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2012-04-01 – 2015-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔衛生学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 24593176","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24593176/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-29"}],"displaytype":"detail","filename":"24593176.pdf","filesize":[{"value":"686.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"24593176","url":"https://tsurumi-u.repo.nii.ac.jp/record/1215/files/24593176.pdf"},"version_id":"c287e423-6d9a-4721-ac62-61b5c183e295"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔バイオフィルム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エンドトキシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"グラム陽性菌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"グラム陰性菌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"3DS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"菌血症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"TAKEUCHI, Hiroaki","creatorNameLang":"en"},{"creatorName":"武内, 博朗","creatorNameLang":"ja"},{"creatorName":"タケウチ, ヒロアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"TAKEUCHI","familyNameLang":"en"},{"familyName":"武内","familyNameLang":"ja"},{"familyName":"タケウチ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"},{"givenName":"博朗","givenNameLang":"ja"},{"givenName":"ヒロアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"796","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50572260","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50572260"},{"nameIdentifier":"796","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔バイオフィルムのグラム陰性菌/陽性菌比率と病原性の形態的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔バイオフィルムのグラム陰性菌/陽性菌比率と病原性の形態的解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of gram-positive/negative bacteria ratio and pathogenicity of oral biofilm","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["181"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-29"},"publish_date":"2022-04-29","publish_status":"0","recid":"1215","relation_version_is_last":true,"title":["口腔バイオフィルムのグラム陰性菌/陽性菌比率と病原性の形態的解析"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T23:18:41.063724+00:00"}