{"created":"2023-05-15T08:55:57.277671+00:00","id":1197,"links":{},"metadata":{"_buckets":{"deposit":"a737f76f-0846-4943-b54b-6f3a4f091a4f"},"_deposit":{"created_by":10,"id":"1197","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1197"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001197","sets":["100:101:103:178"]},"author_link":["894"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ヒト葉系組織中に多分化能を有するものの、造腫瘍性を持たないMuse細胞が報告された。本研究では医療廃棄物である臍帯組織中のMuse細胞とゼラチンハイドロゲルを用いた組織工学的歯周組織再生療法開発を目指した。我々の過去に報告した方法で臍帯より細胞を得て、それを東北大学大学院医学系研究科細胞組織学分野のプロトコールに従いSSEA-3、CD105でソーティングした結果、臍帯組織に多分可能を有するMuse細胞は認められた。またゼラチンハイドロゲルはヒト臨床研究の結果その有効性が示された。本研究は鶴見大学歯学部倫理審査委員会の承認のもと行った（受付番号：1203号）","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：It has been reported that human stem tissues contain Muse cells, which have multilineage potential but do not have neoplasm generating characteristics. The purpose of this study is the development of tissue-engineering, periodontal regenerative therapy by using Muse cells in umbilical cord tissue, which is medical waste, and a gelatine hydrogel. As a result of sorting the cells, which were obtained from an umbilical cord by a method that we have reported on in the past, using SSEA-3, CD105 according to cytohistology protocols at the Graduate School of Medicine, Tohoku University, it was observed that the umbilical cord tissue had Muse cells with multilineage potential. In addition, the effectiveness of a gelatine hydrogel was confirmed as a result of human clinical studies. This study was performed under the authorization of the ethical review committee of the Faculty of Dentistry, Tsurumi University (receipt number: No.1203).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2015(平成27)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2013-04-01 – 2016-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：歯周組織再生","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 25670836","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25670836/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"25670836.pdf","filesize":[{"value":"476.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"25670836","url":"https://tsurumi-u.repo.nii.ac.jp/record/1197/files/25670836.pdf"},"version_id":"1c6177df-6ea7-4419-9891-d87711d126d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Muse細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"臍帯","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"臍帯由来間葉系細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周組織再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再生医学・医療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再生医工学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼラチンハイドロゲル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KANAZASHI, Mikimoto","creatorNameLang":"en"},{"creatorName":"金指, 幹元","creatorNameLang":"ja"},{"creatorName":"カナザシ, ミキモト","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KANAZASHI","familyNameLang":"en"},{"familyName":"金指","familyNameLang":"ja"},{"familyName":"カナザシ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Mikimoto","givenNameLang":"en"},{"givenName":"幹元","givenNameLang":"ja"},{"givenName":"ミキモト","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"894","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80339811","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80339811"},{"nameIdentifier":"894","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"臍帯由来間葉系細胞中Muse細胞の特性解析と歯周組織再生医療応用への展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臍帯由来間葉系細胞中Muse細胞の特性解析と歯周組織再生医療応用への展開","subitem_title_language":"ja"},{"subitem_title":"An analysis of the characteristics of Muse cells in mesenchymal cells obtained from umbilical cords, and the development of periodontal regenerative therapy applications","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["178"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"1197","relation_version_is_last":true,"title":["臍帯由来間葉系細胞中Muse細胞の特性解析と歯周組織再生医療応用への展開"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T03:15:24.068080+00:00"}