{"created":"2023-05-15T08:55:56.963679+00:00","id":1190,"links":{},"metadata":{"_buckets":{"deposit":"b4c95e6d-5556-4fbd-8e88-823ae9193de4"},"_deposit":{"created_by":10,"id":"1190","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1190"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001190","sets":["100:101:103:178"]},"author_link":["890"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：歯周病は歯を支えている歯周組織（歯肉、歯根膜、歯槽骨、セメント質）に炎症が及ぶ疾患である。本研究では歯周病の特徴である歯槽骨の吸収を抑える因子として、好中球エラスターゼ阻害剤に着目した。これまでに好中球エラスターゼがまず始めに歯根膜のコラーゲン線維間基質である糖タンパク質を破壊し、これにより歯根膜の破壊が進行することを示してきた。本研究では、好中球エラスターゼが歯根膜のみではなく、組織学的に歯根膜に隣接している歯槽骨の破壊にも同時に影響していることを調べ、それが好中球エラスターゼの阻害剤によって抑制されていることを示唆した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Periodontal disease is extending inflammation to the periodontal tissue: gingival tissue, periodontal ligaments, alveolar bone, cementum. In this project, the inhibitor of neutrophil elastase (NE) is focused on its function that is one of the factor of suppressive alveolar bone loss. Previously, it has demonstrated the NE resolved the glycoprotein, existing a substrate among collagen fibers firstly. Then, degradation of periodontal ligament is progressing. In this experiment, it is histologically examined that NE affects not only the degradation of periodontal ligament but also, alveolar bone which is adjacent to periodontal ligaments. For that reason, the effects of the NE investigated using the inhibitor of neutrophil elastase (Sivelestat). As result, the Sivelestat group recovered the number of osteoclasts which is surrounding of periodontal pocket compare with the group of without Sivelestat. Therefore, it is suggested that Sivelestat suppressive acts on alveolar bone loss.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2015(平成27)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2013-04-01 – 2016-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 25870843","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25870843/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"25870843.pdf","filesize":[{"value":"345.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"25870843","url":"https://tsurumi-u.repo.nii.ac.jp/record/1190/files/25870843.pdf"},"version_id":"ed747cdf-f19d-461b-8093-1845af2afa26"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球エラスターゼ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨吸収","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"UJIIE, Yuko","creatorNameLang":"en"},{"creatorName":"氏家, 優子","creatorNameLang":"ja"},{"creatorName":"ウジイエ, ユウコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"UJIIE","familyNameLang":"en"},{"familyName":"氏家","familyNameLang":"ja"},{"familyName":"ウジイエ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yuko","givenNameLang":"en"},{"givenName":"優子","givenNameLang":"ja"},{"givenName":"ユウコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"890","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60588599","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60588599"},{"nameIdentifier":"890","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"好中球エラスターゼ阻害剤を歯周病治療薬として用いる基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"好中球エラスターゼ阻害剤を歯周病治療薬として用いる基礎的研究","subitem_title_language":"ja"},{"subitem_title":"Elementary research for making use of the inhibitor of neutrophil elastase as periodontal disease treatment.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["178"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"1190","relation_version_is_last":true,"title":["好中球エラスターゼ阻害剤を歯周病治療薬として用いる基礎的研究"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T03:09:19.140093+00:00"}