{"created":"2023-05-15T08:55:56.518533+00:00","id":1181,"links":{},"metadata":{"_buckets":{"deposit":"4735c2c6-f16d-4fdf-ab12-d15a78273cd8"},"_deposit":{"created_by":10,"id":"1181","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1181"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001181","sets":["100:101:103:178"]},"author_link":["884"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Zip13はⅠ型コラーゲンの生合成に強く関与していることが示唆される遺伝子である。そのため、Zip13KOマウスの歯根象牙質で生じた質的な異常の多くはⅠ型コラーゲンの異常であると思われるが、Ⅴ型コラーゲンの発現も解明できるのではないかと考えた。しかしながら、ISHや免染などでⅤ型コラーゲンの異常は見られなかった。Ⅰ型コラーゲンの発現部位はWTマウスでは歯槽骨、KOマウスでは歯槽骨と歯根象牙質における質的な異常を示す成長線様の縞模様部であった。よって、歯根象牙質の異常はⅠ型コラーゲンの異常だけでなく、象牙質に特有なDSPPやDSPのような非コラーゲン性タンパク質の異常もあることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：It is reported that the Slc39a/Zip13 is related to biosynthesis of Type I collagen. Although Zip13 KO mice in root dentine observe the qualitative abnormality for type I collagen, it is still obscure to the onset of Type V collagen. In this study we observed to the onset of type V collagen. As results, the reaction to the antibody of type V and III collagen were not observed both in Zip13 WT and KO mice by ISH. However, the antibody of type I was reacted at alveolar bone in Zip13 WT mice, but observed in not only at alveolar bone but also in root abnormal dentine in Zip13 KO mice by immunohistochemical staining. All over results suggests that the non-collagenous protein such as DSPP, and/or DSP are related to the deposition of qualitative abnormal root dentine in Zip13 KO mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2015(平成27)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2013-04-01 – 2016-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：小児歯科学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 25463202","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25463202/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"25463202.pdf","filesize":[{"value":"94.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"25463202","url":"https://tsurumi-u.repo.nii.ac.jp/record/1181/files/25463202.pdf"},"version_id":"3624e035-6964-40da-8f6e-80e0550c91fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Zio13","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Zip13KOマウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Ⅰ型コラーゲン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"鍍銀染色","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫染色","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"象牙質形成不全症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根象牙質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"象牙芽細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"IDAIRA, Yayoi","creatorNameLang":"en"},{"creatorName":"伊平, 弥生","creatorNameLang":"ja"},{"creatorName":"イダイラ, ヤヨイ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"IDAIRA","familyNameLang":"en"},{"familyName":"伊平","familyNameLang":"ja"},{"familyName":"イダイラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yayoi","givenNameLang":"en"},{"givenName":"弥生","givenNameLang":"ja"},{"givenName":"ヤヨイ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"884","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40200018","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40200018"},{"nameIdentifier":"884","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新しい象牙質形成不全症モデルを用いたV型コラーゲンの発現機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新しい象牙質形成不全症モデルを用いたV型コラーゲンの発現機序の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the collagen type 5 expression mechanism in new DI model mice","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["178"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"1181","relation_version_is_last":true,"title":["新しい象牙質形成不全症モデルを用いたV型コラーゲンの発現機序の解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T02:55:53.590247+00:00"}