{"created":"2023-05-15T08:55:56.268288+00:00","id":1177,"links":{},"metadata":{"_buckets":{"deposit":"121b4406-0ee9-4c8a-ab72-2a8ebee85562"},"_deposit":{"created_by":10,"id":"1177","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1177"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001177","sets":["100:101:103:178"]},"author_link":["769"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：口腔カンジダ症はカンジダ属真菌による口腔粘膜の感染症であり、その病態は、さまざまである。その原因は宿主の免疫能の低下など日和見感染として発症する側面と、菌交代現象を背景として発症するなどきわめて複雑である。そこで本研究では、より効果的で簡便な新しい口腔カンジダ症予防法、治療法の開発の可能性につき検討した。口腔内より分離されるカンジダ属真菌４種に対し、405nm青紫色レーザー光は、増殖抑制効果を有していた。このことは、405nm青紫色レーザー光を利用した口腔内カンジダ属真菌の制御が可能なことを示しており、口腔カンジダ症に対する新たな低侵襲予防法、治療法確立の可能性を示唆するものと考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Although oral candidiasis, an opportunistic infection caused by Candida species, has been conventionally treated by topical and/or systemic administration of antifungal agents, this mediation therapy is prone to raise the drug resistance of Candida species as well as multiple side effects. Therefore, it is important to establish a minimally invasive therapeutic strategy and prophylactic approach for oral candidiasis. Here, we focused on photodynamic therapy with 405-nm blue light, and examined the effect of 405-nm blue light irradiation on the growth of Candida albicans (C. albicans). Results: Irradiations at 200 mW of the output for 10 and 20 minuets showed about 55 % and 90 % significant growth inhibition, respectively. C. albicans growth was suppressed by 405-nm blue light irradiation, suggesting that 405-nm blue light irradiation is a promising means for treatment and prevention of oral candidiasis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2015(平成27)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2013-04-01 – 2016-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 25463102","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25463102/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"25463102.pdf","filesize":[{"value":"868.3 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"25463102","url":"https://tsurumi-u.repo.nii.ac.jp/record/1177/files/25463102.pdf"},"version_id":"a57d339a-a15c-4679-8594-718d711861cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔カンジダ症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"光線力学療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"405nmレーザー光","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"YAMACHIKA, Shigeo","creatorNameLang":"en"},{"creatorName":"山近, 重生","creatorNameLang":"ja"},{"creatorName":"ヤマチカ, シゲオ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"YAMACHIKA","familyNameLang":"en"},{"familyName":"山近","familyNameLang":"ja"},{"familyName":"ヤマチカ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Shigeo","givenNameLang":"en"},{"givenName":"重生","givenNameLang":"ja"},{"givenName":"シゲオ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"769","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60182565","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60182565"},{"nameIdentifier":"769","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"405nm青紫色レーザー光による新規口腔カンジタ症治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"405nm青紫色レーザー光による新規口腔カンジタ症治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Possible application of 405-nm blue light irradiation for the treatment and the prevention of oral candidiasis","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["178"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"1177","relation_version_is_last":true,"title":["405nm青紫色レーザー光による新規口腔カンジタ症治療法の開発"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:35:41.990658+00:00"}