{"created":"2023-05-15T08:55:55.610518+00:00","id":1165,"links":{},"metadata":{"_buckets":{"deposit":"3c8bd62a-c58d-43d7-83e0-193b442a850d"},"_deposit":{"created_by":10,"id":"1165","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1165"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001165","sets":["100:101:103:177"]},"author_link":["872"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：咀嚼筋は四肢の骨格筋と同様に可塑性を有し、その表現型や生理機能は様々な咬合の状態に適応することが報告されている。しかしながら、その適応機構の詳細は未だ不明な点が多い。本研究では、実験動物にマウスを用い、咬筋とヒラメ筋における強制的開口(BO)による筋肥大効果および、それに対するデキサメタゾン（DEX）の拮抗作用について検討した。今回の結果から、咬筋とヒラメ筋ではDEXに対する感受性またはその作用機序が異なることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Masticatory muscles have the potential to adapt their mass and fiber types to a wide range of functional demands, as observed in limb muscles. However, these molecular mechanisms are poorly understood. In this study, we analyzed the effects of bite-opening treatment (BO) on muscle phenotypes of mice masseter muscle. To examine hypertrophic effects of BO on masseter and soleus muscles as well as antagonistic action of dexamethasone (DEX), a glucocorticoid, against hypertrophy, we analyzed both muscle mass and fiber diameter of masseter, soleus muscles in BO and/or DEX-treated mice. These results suggest that differences in the sensitivity to DEX or in the mechanisms of DEX antagonism between masseter and soleus muscles.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2014-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：歯科矯正学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 26861803","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861803/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"26861803.pdf","filesize":[{"value":"474.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"26861803","url":"https://tsurumi-u.repo.nii.ac.jp/record/1165/files/26861803.pdf"},"version_id":"7e83f75c-35f5-4796-8077-5daeec00989f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"咀嚼筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"デキサメタゾン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"筋萎縮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅木, 大輔","creatorNameLang":"ja"},{"creatorName":"UMEKI, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マウス咀嚼筋適応機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス咀嚼筋適応機構の解明","subitem_title_language":"ja"},{"subitem_title":"Masticatory muscle plasticity in mouse","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1165","relation_version_is_last":true,"title":["マウス咀嚼筋適応機構の解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-01-15T02:32:22.242771+00:00"}