{"created":"2023-05-15T08:55:55.559325+00:00","id":1164,"links":{},"metadata":{"_buckets":{"deposit":"dc25b1ae-069f-4ea7-97c5-6d12fd855285"},"_deposit":{"created_by":10,"id":"1164","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1164"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001164","sets":["100:101:103:177"]},"author_link":["871"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：歯科矯正治療における歯の移動時の牽引側歯根膜線維芽細胞の骨芽細胞への分化について、ヒストン３の９番目のリジン(H3K9)のメチル化修飾に焦点を絞り、エピジェネティクスという観点からその分化を明らかにすることを目的とした。その結果、歯の移動後７日目をピークとして歯根膜線維芽細胞でメチル化修飾を受けるという変化が観察された。また、牽引側の歯根膜線維芽細胞でH3K9メチル化修飾酵素が働き、経時的なH3K9メチル化修飾変化が生じていることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The purpose of this study was to clarify the osteoblasts differentiation of periodontal ligament fibroblasts in tension zone during orthodontic tooth movement, focusing on methylation modification at histone H3 lysine 9 (H3K9) from the view point of epigenetics control. We observed the changes that localization of methylated H3K9 modifications with peak at 7th days after tooth movement in periodontal ligament fibroblasts. In addition, it was suggested that the H3K9 methyltransferases acted in the periodontal ligament fibroblasts in the tension zone and the H3K9 methylation modification change was occurred in time-dependent.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2014-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 26861802","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861802/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"26861802.pdf","filesize":[{"value":"593.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"26861802","url":"https://tsurumi-u.repo.nii.ac.jp/record/1164/files/26861802.pdf"},"version_id":"29913cd8-5547-4cdb-98a1-c9ab0b448e05"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯科矯正治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根膜線維芽細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エピジェネティクス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"ISHIKAWA, Misao","creatorNameLang":"en"},{"creatorName":"石川, 美佐緒","creatorNameLang":"ja"},{"creatorName":"イシカワ, ミサオ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"ISHIKAWA","familyNameLang":"en"},{"familyName":"石川","familyNameLang":"ja"},{"familyName":"イシカワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Misao","givenNameLang":"en"},{"givenName":"美佐緒","givenNameLang":"ja"},{"givenName":"ミサオ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"871","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90582445","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90582445"},{"nameIdentifier":"871","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"歯の移動時の牽引側歯根膜で惹起される骨芽細胞分化のエピジェネティクス制御の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯の移動時の牽引側歯根膜で惹起される骨芽細胞分化のエピジェネティクス制御の解明","subitem_title_language":"ja"},{"subitem_title":"Study of osteoblasts differentiation of periodontal ligament fibroblasts by epigenetic control in tension zone during orthodontic tooth movement","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1164","relation_version_is_last":true,"title":["歯の移動時の牽引側歯根膜で惹起される骨芽細胞分化のエピジェネティクス制御の解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T02:17:54.463841+00:00"}