{"created":"2023-05-15T08:55:55.514378+00:00","id":1163,"links":{},"metadata":{"_buckets":{"deposit":"00582887-1637-4444-90f1-192a40e95689"},"_deposit":{"created_by":10,"id":"1163","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1163"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001163","sets":["100:101:103:177"]},"author_link":["870"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):研究代表者は、骨・骨膜間の間隙を拡大することにより、生体が本来備えている骨修復能を賦活し、骨表面に必要なだけの骨再生を誘導する研究を行っている。本研究では組織延長術を用い骨・骨膜間空隙を拡大することにより、細胞の足場の形成が促進されていることに着目し、骨髄由来間葉系幹細胞と自己フィブリンゲルを注入することにより、臨床応用可能な骨増生法の開発を行った。新たに開発した骨膜延長装置と組み合わせて、間葉系幹細胞+フィブリンゲルを注入する実験を継続したが、骨表面に新生骨を認めるが、骨膜延長群、細胞注入群に比較して骨・骨膜間空隙の全体として骨形成を大きく促進させるまでには至らなかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要(英文):We are investigating to regenerate bone by osteogenesis by gradually expanding the interface between bone surface and periosteum.In this study we deveroped the new bone argmentation to obtain alternative strategies for periosteal distraction to induce effective bone formation that will lead to a reduction of the treatment period and to obtain functional bone capable of withstanding occlusal force.The experimental group of fibrin geland MSC showed significantly increased volume in newly formed bone tissues compared with the control group at critical size defect.However micro-CT and histological analysis demonstrated that the effects of periosteal distraction were not enhanced by administration of bone marrow stem cells and fibrin gel.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度):2014-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野:医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 26861702","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861702/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"26861702.pdf","filesize":[{"value":"219.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"26861702","url":"https://tsurumi-u.repo.nii.ac.jp/record/1163/files/26861702.pdf"},"version_id":"42ed6079-be12-4a16-91be-1a61a98e9d09"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨膜","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"SATO, Koichiro","creatorNameLang":"en"},{"creatorName":"佐藤, 光一郎","creatorNameLang":"ja"},{"creatorName":"サトウ, コウイチロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"SATO","familyNameLang":"en"},{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Koichiro","givenNameLang":"en"},{"givenName":"光一郎","givenNameLang":"ja"},{"givenName":"コウイチロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"870","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20728125","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20728125"},{"nameIdentifier":"870","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨・骨膜間空隙の拡大による骨増量法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨・骨膜間空隙の拡大による骨増量法の確立","subitem_title_language":"ja"},{"subitem_title":"Osteogenesis by gradually expanding the interface between bone surface and periosteum","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1163","relation_version_is_last":true,"title":["骨・骨膜間空隙の拡大による骨増量法の確立"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T02:16:03.666568+00:00"}