{"created":"2023-05-15T08:55:55.425006+00:00","id":1161,"links":{},"metadata":{"_buckets":{"deposit":"fc4a4f7d-7324-46d9-9cb1-de88958ffd83"},"_deposit":{"created_by":10,"id":"1161","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1161"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001161","sets":["100:101:103:177"]},"author_link":["868"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では歯・インプラント・顎骨・歯根膜の相互作用の解明について多方向よりアプローチし、成長因子の機能と細胞増殖分化制御に関する新たな知見を得た。1. ヒト歯根膜細胞6株を樹立し、すべての細胞株でTGF-βにより骨芽細胞分化が促進し、BMPによって抑制された。2. レーザー照射によって発現の上昇が認められたMMPは、細胞内TGF-βの活性化に関与する。3. 幼若エナメル質ではTGF-β1が、成熟期エナメル質ではTGF-β1とβ3が共存する。4. 樹立した歯髄細胞株は象牙芽細胞分化能を有しており、TGF-βおよびBMPによる分化誘導によってDSPP、MMP-20の遺伝子を発現した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：This study approached from a variety of angles which focus on interface of the dental implants and the alveolar bone. New knowledge was obtained it about growth factors affect the proliferation and differentiation of mesenchymal cells. 1. Six human periodontal ligament (HPDL) cell lines were picked up, TGF-β and BMP regulated osteoblastic differentiation of all cell lines. 2. Intracellular TGF-β was activated by MMPs enhanced in HPDL cells by Er:YAG laser irradiation. 3. We identified TGF-β isoforms in porcine immature and mature enamel of developing teeth. These results suggest that TGF-β1 is predominant in the secretory-stage enamel, while both TGF-β1 and β3 coexist in the maturation-stage enamel. 4. We established cell lines from porcine dental pulp and examined the effects of BMP2 and TGF-β on the odontoblastic differentiation. After differentiation, odontoblastic cells were expressed the gene of DSPP and MMP-20.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：生化学　分子生物学　歯周病学　歯科インプラント学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K21457","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K21457/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"15K21457.pdf","filesize":[{"value":"373.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K21457","url":"https://tsurumi-u.repo.nii.ac.jp/record/1161/files/15K21457.pdf"},"version_id":"499a6425-c7e2-4575-8543-881994aaa880"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周組織再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根膜付きインプラント","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖分化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"成長因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"オッセオインテグレーション","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ジルコニア","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"SAITO, Mari","creatorNameLang":"en"},{"creatorName":"斉藤, まり","creatorNameLang":"ja"},{"creatorName":"サイトウ, マリ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"SAITO","familyNameLang":"en"},{"familyName":"斉藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Mari","givenNameLang":"en"},{"givenName":"まり","givenNameLang":"ja"},{"givenName":"マリ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"868","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60739332","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60739332"},{"nameIdentifier":"868","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ジルコニアおよびチタン上培養細胞における骨芽細胞分化能の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ジルコニアおよびチタン上培養細胞における骨芽細胞分化能の比較","subitem_title_language":"ja"},{"subitem_title":"Differentiation potential of osteoblast from cultured C2C12 cells on zirconia disk.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1161","relation_version_is_last":true,"title":["ジルコニアおよびチタン上培養細胞における骨芽細胞分化能の比較"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T02:11:13.388634+00:00"}