{"created":"2023-05-15T08:55:55.243202+00:00","id":1157,"links":{},"metadata":{"_buckets":{"deposit":"13843842-2985-4d53-ac37-9e0abe0ca8f8"},"_deposit":{"created_by":10,"id":"1157","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1157"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001157","sets":["100:101:103:177"]},"author_link":["866"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究課題では歯や骨の再生に関連し以下のことを明らかにした。1)DSPPのスプライスバリアントは歯髄および象牙芽細胞で異なって調節されている。2)形成過程のエナメル質中のTGF-β1活性化および不活性化はMMP20およびKLK4によって行われ、組織内の移送や活性の維持にはamelogeninが必要である。3)生理活性物質を含む脱灰骨のシートは歯槽骨を優位に増大させる。4)NGFの局所注射は糖尿病ラットのインプラント－骨接触率を改善する。5) TGF-βは生理的乳歯歯根吸収の歯根周囲組織におけるRANKLおよびOPGのmRNAの発現時期に依存して破骨細胞分化の調節に密接に関与している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：This study revealed the following concerning the regeneration of teeth and bones. 1) The splice variant of specific mRNAs of DSPP is regulated differently in pulp and differentiated odontoblasts. 2) TGF-β1 is activated or inactivated by MMP20 or KLK4 and that the amelogenin cleavage product is necessary for the in-solution mobility of TGF-β1, which is necessary for binding to its receptor on ameloblasts and retention of its activity. 3) Conditions using demineralized bone sheet with biologically active substances significantly augmented the height of the alveolar bone. 4) Local injection of NGF could improve implant-bone osseointegration in diabetic rats. 5) TGF-β is closely related to the regulation of both OPG induction and RANKL-mediated osteoclast differentiation, depending on the timing of the mRNA expression of RANKL and OPG factors in the root-surrounding tissues of deciduous teeth during physiological root resorption.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：生化学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K20491","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K20491/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"15K20491.pdf","filesize":[{"value":"493.7 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K20491","url":"https://tsurumi-u.repo.nii.ac.jp/record/1157/files/15K20491.pdf"},"version_id":"f0485271-4074-4cc6-8fcb-3e2dc2b6ece9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯科インプラント","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周組織","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"YAMAMOTO, Ryuji","creatorNameLang":"en"},{"creatorName":"山本, 竜司","creatorNameLang":"ja"},{"creatorName":"ヤマモト, リュウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"YAMAMOTO","familyNameLang":"en"},{"familyName":"山本","familyNameLang":"ja"},{"familyName":"ヤマモト","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ryuji","givenNameLang":"en"},{"givenName":"竜司","givenNameLang":"ja"},{"givenName":"リュウジ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"866","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20410053","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20410053"},{"nameIdentifier":"866","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"間葉系幹細胞を利用した歯周組織再生型インプラント開発のための基礎研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"間葉系幹細胞を利用した歯周組織再生型インプラント開発のための基礎研究","subitem_title_language":"ja"},{"subitem_title":"Basic study for development of periodontal tissue regenerative implant using mesenchymal stem cells","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1157","relation_version_is_last":true,"title":["間葉系幹細胞を利用した歯周組織再生型インプラント開発のための基礎研究"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T02:07:13.116843+00:00"}