{"created":"2023-05-15T08:55:54.841905+00:00","id":1148,"links":{},"metadata":{"_buckets":{"deposit":"b99ae2ad-9762-4192-aad8-15f3e973db4a"},"_deposit":{"created_by":10,"id":"1148","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1148"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001148","sets":["100:101:103:177"]},"author_link":["774"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：口腔癌のがん幹細胞を標的とした光線免疫療法（PIT）の開発を目的に行った。近赤外線照射装置およびフタロシアニンと抗CD44v9抗体の複合体(F-antiCD44v9)を作製した。ヒト口腔癌細胞株にF-antiCD44v9を作用させた後に近赤外線を照射する（PIT）とがん細胞膜が破壊され徐々に死滅することを確認した。しかし、固形がんに近い状態で培養した口腔癌細胞に対してはPITの抗腫瘍効果はみられなかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The aim of this research was to develop photo-immunotheray (PIT) targeting in cancer stem cells of oral cancer. The equipment for irradiation of near-infrared light and the phthalocyanine-anti CD44v9 antibody composite (F-antiCD44v9) were prepared. We performed the PIT using F-antiCD44v9 on human oral observed that PIT destroyed the cell membrane of cancer cells by PIT. However, PIT did not have anti-tumor effect on the cancer cells which forms the spheroids like a solid cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2014-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 26463028","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26463028/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"26463028.pdf","filesize":[{"value":"267.6 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"26463028","url":"https://tsurumi-u.repo.nii.ac.jp/record/1148/files/26463028.pdf"},"version_id":"d0ae1fb2-e1a0-4797-b365-7b1ba2f1a225"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"低侵襲治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"光線免疫療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"がん幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"標的癌治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"舘原, 誠晃","creatorNameLang":"ja"},{"creatorName":"TATEHARA, Seiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん幹細胞を標的とした光線免疫療法による低侵襲口腔癌治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん幹細胞を標的とした光線免疫療法による低侵襲口腔癌治療の開発","subitem_title_language":"ja"},{"subitem_title":"Development of minimum-invasive oral cancer therapy using photo-immunotherapy targeted on cancer stem cells","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1148","relation_version_is_last":true,"title":["がん幹細胞を標的とした光線免疫療法による低侵襲口腔癌治療の開発"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-01-15T02:32:24.739211+00:00"}