{"created":"2023-05-15T08:55:54.780151+00:00","id":1147,"links":{},"metadata":{"_buckets":{"deposit":"9464547c-ddde-415d-9cac-7abc2b67aeb3"},"_deposit":{"created_by":10,"id":"1147","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1147"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001147","sets":["100:101:103:177"]},"author_link":["857"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：唾液分泌に果たすシスタチンの役割を検討した。唾液中のシスタチンはシェーグレン症候群患者において著明に減少していた。シェーグレン症候群の口唇腺は、漿液腺房や粘液腺房の形態的変化が大きいほどTUNEL染色陽性細胞が多く、また、形態的変化が強い唾液腺組織では漿液半月のシスタチンＳが低下していた。スタウロスポリンで処理してアポトーシスを誘導した培養細胞HSG cellに、シスタチンを添加するとアポトーシス阻害効果が認められた。以上のようなことから、シェーグレン症候群における唾液分泌低下は、アポトーシス制御機能の破綻で生じ、この破壊はシスタチンによって制御できる可能性があること示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The purpose of this study was to clarify the role of cystatin in the salivary secretion observed in a Sjogren's syndrome patient. The secretion of salivary cystatin significantly decreased in the Sjogren's syndrome patient significantly. In Sjogren's syndrome patients, there were many TUNEL positive cells tend to be observed in the serous and mucous acinar cells of the labial glands. The more morphological change that is observed, the less cystatin S intensity that is seen in the serous demilunes of the salivary gland. TheAn inhibition of apoptosis was observed when cystatin S was added to the apoptosis-induced cultured HSG cells. These results suggested that one of the causes of hyposalivation in Sjogren's syndrome is likelywas the failure of the apoptotic control function by cystatin, and thus the administration of applying cystatin S may have allowed the patient to overcome this problempossibly controlled the failure.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2014-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 26463027","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26463027/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"26463027.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"26463027","url":"https://tsurumi-u.repo.nii.ac.jp/record/1147/files/26463027.pdf"},"version_id":"f930ec62-454f-4712-be85-0a8b6c89b1e6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シェーグレン症候群","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シスタチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液分泌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"NAKAGAWA, Yoichi","creatorNameLang":"en"},{"creatorName":"中川, 洋一","creatorNameLang":"ja"},{"creatorName":"ナカガワ, ヨウイチ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"NAKAGAWA","familyNameLang":"en"},{"familyName":"中川","familyNameLang":"ja"},{"familyName":"ナカガワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoichi","givenNameLang":"en"},{"givenName":"洋一","givenNameLang":"ja"},{"givenName":"ヨウイチ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"857","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90148057","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90148057"},{"nameIdentifier":"857","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"唾液分泌促進に果たすシスタチンの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"唾液分泌促進に果たすシスタチンの役割","subitem_title_language":"ja"},{"subitem_title":"Role of cystatin in salivary secretion","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1147","relation_version_is_last":true,"title":["唾液分泌促進に果たすシスタチンの役割"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T01:39:57.125961+00:00"}