{"created":"2023-05-15T08:55:54.713942+00:00","id":1146,"links":{},"metadata":{"_buckets":{"deposit":"bc763313-0f0c-4e42-86b6-b44c8bec02d3"},"_deposit":{"created_by":10,"id":"1146","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1146"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001146","sets":["100:101:103:177"]},"author_link":["856"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：臨床応用を目的とした歯周組織再生のため、歯根膜由来の幹細胞の特性と歯周組織への分化誘導機構の解明を試みた。歯周組織の再生に有効なことが報告されているブタのエナメルタンパク質中にはBMPやTGF-βの活性が高く、その存在は抗体を用いたELISA法でも確認された。歯根膜組織では TGF-β活性は認められたがBMP活性は認められなかった。歯根膜由来の培養幹細胞を用いた研究で、BMPやTGF-βは歯周組織の分化マーカー遺伝子の発現を促進し、石灰化も促進した。これらの結果から、TGF-β とBMPは臨床的の歯周組織再生のための有効な因子であると思われる。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：We studied the stem cells in the periodontal ligament to investigate the mechanism of periodontal cell differentiation for clinical usage.It has been reported that the porcine enamel proteins activated the periodontal tissue regeneration. We found BMP and TGF-βlike activity in the enamel proteins and identified TGF-β using ELISA method. We also found TGF-β in the periodontal ligament tissue but did not find BMP. BMP and TGF-βstimulated the gene expression of the differentiation maker of the periodontal tissues and mineralization in culture system of periodontal ligament cells.These results suggest that BMP and TGF-βare important factors for periodontal tissue differentiation and clinical usage.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2016(平成28)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2014-04-01 – 2017-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：医歯薬学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 26462983","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26462983/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-19"}],"displaytype":"detail","filename":"26462983.pdf","filesize":[{"value":"391.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"26462983","url":"https://tsurumi-u.repo.nii.ac.jp/record/1146/files/26462983.pdf"},"version_id":"264a0852-f5ae-4a0e-8369-06994ae92a3a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周組織再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根膜","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"硬組織","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"OIDA, Shinichiro","creatorNameLang":"en"},{"creatorName":"大井田, 新一郎","creatorNameLang":"ja"},{"creatorName":"オオイダ, シンイチロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OIDA","familyNameLang":"en"},{"familyName":"大井田","familyNameLang":"ja"},{"familyName":"オオイダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Shinichiro","givenNameLang":"en"},{"givenName":"新一郎","givenNameLang":"ja"},{"givenName":"シンイチロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"856","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10114745","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10114745"},{"nameIdentifier":"856","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"歯根膜由来の幹細胞の特性と歯周組織への分化誘導機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯根膜由来の幹細胞の特性と歯周組織への分化誘導機構の解明","subitem_title_language":"ja"},{"subitem_title":"Characteristic of the stem cells in periodontal ligament and differentiation mechanism of the periodontal tissues from the stem cells.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["177"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-19"},"publish_date":"2022-04-19","publish_status":"0","recid":"1146","relation_version_is_last":true,"title":["歯根膜由来の幹細胞の特性と歯周組織への分化誘導機構の解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T01:37:37.424098+00:00"}