{"created":"2023-05-15T08:55:52.883581+00:00","id":1112,"links":{},"metadata":{"_buckets":{"deposit":"ed59db28-5f03-4e8f-bd9a-7bbc7cd68174"},"_deposit":{"created_by":1,"id":"1112","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"1112"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001112","sets":["100:104:106:167"]},"author_link":["838"],"control_number":"1112","item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、口腔がん細胞の転移・浸潤のメカニズムについて、PARP阻害剤を投与することによって生じる変化について比較検証した。3種類の口腔がん細胞、PARP阻害剤はオラパリブを使用した。初年度は、細胞レベルにおいて、オラパリブが①接着能、②遊走能、③浸潤能それぞれを低下させることを明らかにした。次年度は、口腔がん細胞をヌードマウスの咬筋付近に移植して腫瘍を形成させ、オラパリブ投与群とコントロール群における腫瘍の下顎骨への浸潤程度を比較検証した。①画像所見、②病理組織学的評価、③浸潤能関連因子の免疫組織学的評価を行い、オラパリブ投与によって、in vivoでも浸潤能が低下することが分かった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：In this report, mechanism of oral cancer invasion and metastasis was analyzed using PARP inhibitor which is one of molecular target drugs and currently under clinical trial for breast cancer. Materials used in this reports are three kinds of oral cancer derived cells, Ca9-22, SAS, and HSC-2 and Olaparib (AZD2281) as PARP inhibitor. In the first year, PARP inhibitor showed significant decrease of 1) cell proliferation, 2) cell migration, 3) cell infiltration, and 4) cell adhesion except cell (Ca9-22) adhesion for laminin coating, which showed significant increase of cell adhesion using with Olaparib. Next, xenografted tumors were generated by injection of tumor cells into masseter muscles. Tumor volumes of control group mice increased during the experimental period. However, tumor growth rate of AZD2281 group significantly decreased compared to the control group after tumor cell injection. Xenografted tumor invasion to mandibule was also compared between Olaparib/control groups.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K11286","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K11286/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"15K11286.pdf","filesize":[{"value":"709.7 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K11286","url":"https://tsurumi-u.repo.nii.ac.jp/record/1112/files/15K11286.pdf"},"version_id":"09de64e9-0c4a-4c17-8fb5-c22df02eee80"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔がん","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"転移","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"浸潤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分子標的治療薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤原, 久子","creatorNameLang":"ja"},{"creatorName":"FUJIHARA, Hisako","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{"nameIdentifierURI":""}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規分子標的薬による口腔がんの浸潤転移抑制機構の解明と臨床応用に向けた戦略的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規分子標的薬による口腔がんの浸潤転移抑制機構の解明と臨床応用に向けた戦略的研究","subitem_title_language":"ja"},{"subitem_title":"Investigation of potential use of molecular targeted medicine on inhibition of oral cancer invasion and metastasis","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"1","path":["167"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1112","relation_version_is_last":true,"title":["新規分子標的薬による口腔がんの浸潤転移抑制機構の解明と臨床応用に向けた戦略的研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2024-02-13T07:26:40.844422+00:00"}