{"created":"2023-05-15T08:55:52.816533+00:00","id":1111,"links":{},"metadata":{"_buckets":{"deposit":"8cbcaa0a-9b32-4de0-9329-14c275fe71bf"},"_deposit":{"created_by":1,"id":"1111","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"1111"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001111","sets":["100:104:106:167"]},"author_link":["204"],"control_number":"1111","item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：hPDL細胞においてEr:YAGレーザー照射により組織再生に関わる細胞増殖や分化を制御する重要なサイトカインであるTGF-βが活性化された。しかしながら,直接活性化はされず,その活性化にはMMP-2,MMP-3,MMP-8の遺伝子発現が関与し,HSP90αの関与も示唆された。ブタ歯髄組織に対するEr:YAGレーザー照射はALP活性を上昇させる効果を有し,53,45,40 kDaのMMP活性や33 kDaのnon-MMP活性が認められた。ブタ歯髄組織由来の不死化細胞(PPU-7細胞)に対するレーザー照射では,MMP-2遺伝子発現の増強が認められ,TGF-β活性への関与が考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Transforming growth factor-beta (TGF-β), which is an important cytokine that controls cell proliferation and differentiation, was activated in hPDL cells by Er:YAG laser irradiation. However, the direct activation was not done, and MMP-2, MMP-3, MMP-8 gene expression was involved in its activation, suggesting the involvement of HSP90α. Er:YAG laser irradiation on the porcine pulp tissue had an effect of increasing ALP activity, and MMPs activity of 53,45,40 kDa and non-MMP activity of 33 kDa were observed. Enhancement of MMP-2 gene expression was recognized by laser irradiation on immortalized cells (PPU-7 cells) derived from porcine pulp tissue, and it was considered to be involved in TGF-β activity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：歯科医用工学・再生歯学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K11233","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K11233/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"15K11233.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K11233","url":"https://tsurumi-u.repo.nii.ac.jp/record/1111/files/15K11233.pdf"},"version_id":"ca3074bf-2937-4abf-933d-beea8002f5c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Er:YAGレーザー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"hPDL細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯髄細胞(組織)","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"プラスミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"HSP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KOBAYASHI, Kazuyuki","creatorNameLang":"en"},{"creatorName":"小林, 一行","creatorNameLang":"ja"},{"creatorName":"コバヤシ, カズユキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KOBAYASHI","familyNameLang":"en"},{"familyName":"小林","familyNameLang":"ja"},{"familyName":"コバヤシ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kazuyuki","givenNameLang":"en"},{"givenName":"一行","givenNameLang":"ja"},{"givenName":"カズユキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"204","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70288116","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70288116"},{"nameIdentifier":"204","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Er:YAGレーザー併用によるサイトカイン療法の象牙質および歯周組織再生効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Er:YAGレーザー併用によるサイトカイン療法の象牙質および歯周組織再生効果","subitem_title_language":"ja"},{"subitem_title":"Regenerative effect of dentin and periodontal tissue by cytokine therapy induced due to Er:YAG laser combination","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"1","path":["167"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1111","relation_version_is_last":true,"title":["Er:YAGレーザー併用によるサイトカイン療法の象牙質および歯周組織再生効果"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2024-08-01T07:31:21.252181+00:00"}