{"created":"2023-05-15T08:55:52.618712+00:00","id":1108,"links":{},"metadata":{"_buckets":{"deposit":"1f3a0dd2-d8a6-4a6c-b40e-2ee687d02ff7"},"_deposit":{"created_by":10,"id":"1108","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1108"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001108","sets":["100:101:103:165"]},"author_link":["836"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):微生物のフッ化物毒性に対する耐性には2種類のフッ化物輸送タンパク(EricF、CrcB)が寄与していることが知られている。しかしながら、代表的な歯周病関連細菌であるPorphyromonas gingivalis(P. g菌)には前記2種類のフッ化物輸送タンパクは存在しない。また、EricF、CrcBと一部相同なアミノ酸配列を有するタンパクを精査したがフッ化物毒性の抵抗に寄与しなかった。つまり、P. g菌が有する未知のフッ化物耐性メカニズムの存在を示唆する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要(英文):Two unrelated families of fluoride exporters were recognized in microorganisms: EriCF and CrcB that contribute to resistance to fluoride toxicity. However, Porphyromonas gingivalis (P. gingivalis), one of the major periodontopathic bacteria, doesn't possess either EricF or CrcB. Although a number of proteins that contain homologous part of amino acid sequences of CrcB were examined, it has not found the fluoride transporter that contribute to resistance to fluoride toxicity. These suggest unknown mechanism for resistance to fluoride toxicity in P. gingivalis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度):2016-04-01 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野:口腔衛生学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 16K15860","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K15860/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"16K15860.pdf","filesize":[{"value":"281.6 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"16K15860","url":"https://tsurumi-u.repo.nii.ac.jp/record/1108/files/16K15860.pdf"},"version_id":"d4fcfd14-6520-4bf6-a7b5-cf87eccc26a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"フッ化物イオン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"P. gingivalis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"MURATA, Takatoshi","creatorNameLang":"en"},{"creatorName":"村田, 貴俊","creatorNameLang":"ja"},{"creatorName":"ムラタ, タカトシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"MURATA","familyNameLang":"en"},{"familyName":"村田","familyNameLang":"ja"},{"familyName":"ムラタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Takatoshi","givenNameLang":"en"},{"givenName":"貴俊","givenNameLang":"ja"},{"givenName":"タカトシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"836","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10313529","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10313529"},{"nameIdentifier":"836","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"創薬ターゲットとなり得るP. gingivalisのフッ化物輸送タンパクの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"創薬ターゲットとなり得るP. gingivalisのフッ化物輸送タンパクの解明","subitem_title_language":"ja"},{"subitem_title":"Clarification of fluoride transporter that is possible drug discovery target in P. gingivalis","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1108","relation_version_is_last":true,"title":["創薬ターゲットとなり得るP. gingivalisのフッ化物輸送タンパクの解明"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T00:50:31.309885+00:00"}