{"created":"2023-05-15T08:55:52.167958+00:00","id":1101,"links":{},"metadata":{"_buckets":{"deposit":"411fc35e-0426-4e54-a9a4-f41dd60ef1cf"},"_deposit":{"created_by":10,"id":"1101","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1101"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001101","sets":["100:101:103:165"]},"author_link":["835"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：口腔扁平上皮癌の腫瘍周囲のTCR遺伝子ライブラリは原発巣とリンパ節転移巣で異なっていたことより、転移に伴う腫瘍抗原性の変化が示唆された。一方、含関連遺伝子である上皮増殖因子(EGFR)関連遺伝子の発現解析により、口腔扁平上皮癌原発組織におけるErbB1の有意な高発現を認めた。また、リンパ節転移陽性群での有意な低生存率が確認されたため、リンパ節転移陽性群で強発現を呈したErbB4は口腔癌の予後予測を直接反映する有用なバイオマーカーとなり得ることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The host immune responses reflected by the TCR repertoire, differed between primary tumors and metastatic lymph nodes. Overexpression of the epidermal growth factor receptor (EGFR) family is common in oral squamous cell carcinoma (OSCC). These results suggest that lymph node metastasis might be associated with changes in the nature of the primary tumor antigens. The expression level of ErbB1 messenger RNA (mRNA) was markedly increased in OSCC. By comparing the gene expression levels of EGFR family members in OSCC tissues that had lymph node metastasis with those in the absence of lymph node metastasis, we found that ErbB4 mRNA expression was increased significantly. Moreover, we confirmed protein expression of ErbB4 in the cytoplasm and membrane of tumor cells, which was stronger in cases with lymph node metastasis. ErbB4 is an independent marker for lymph node metastasis in OSCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K20570","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K20570/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"15K20570.pdf","filesize":[{"value":"232.8 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K20570","url":"https://tsurumi-u.repo.nii.ac.jp/record/1101/files/15K20570.pdf"},"version_id":"540171a0-49d4-4610-a73c-4e65035d7eab"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"前癌病変","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"EGFR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮増殖因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KUMAGAI, Kenichi","creatorNameLang":"en"},{"creatorName":"熊谷, 賢一","creatorNameLang":"ja"},{"creatorName":"クマガイ, ケンイチ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KUMAGAI","familyNameLang":"en"},{"familyName":"熊谷","familyNameLang":"ja"},{"familyName":"クマガイ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kenichi","givenNameLang":"en"},{"givenName":"賢一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"835","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10518129","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10518129"},{"nameIdentifier":"835","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔癌発生に関わる腫瘍免疫学的解明と早期診断法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔癌発生に関わる腫瘍免疫学的解明と早期診断法の確立","subitem_title_language":"ja"},{"subitem_title":"Establishment of early diagnosis and immunological oral cancer","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1101","relation_version_is_last":true,"title":["口腔癌発生に関わる腫瘍免疫学的解明と早期診断法の確立"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T00:46:10.689466+00:00"}