{"created":"2023-05-15T08:55:51.681388+00:00","id":1092,"links":{},"metadata":{"_buckets":{"deposit":"15be63c0-ed03-4449-86f8-7bfee102f346"},"_deposit":{"created_by":10,"id":"1092","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1092"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001092","sets":["100:101:103:165"]},"author_link":["746"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：チタンは科学的根拠に基づいた安全性が確立された金属として歯科領域や整形外科領域で広く使用されている. しかしながら,チタンアレルギー反応に対する特異的 T 細胞の同定, 誘導機構やT 細胞による抗原認識機構などの詳細は全く不明であり,さらには金属が如何なる生体内蛋白と関係して抗原性を有するのか解明すべきことが多い.本チタンアレルギーモデルマウスにおける解析により, NK T細胞およびMAIT細胞 による自然リンパ球がチタンアレルギーの病態発症および免疫制御に関与している可能性が示唆された.","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Titanium alloy has long been regarded as a biocompatible material, and is widely used for implants in medicine and dentistry. Titanium is thought to be a potential cause of metal allergy, however, accumulating T cells during development of titanium allergy have been poorly characterized because basic research based on a suitable animal model has not been performed. This study aimed to investigate the skewing of the T-cell receptor repertoire and cytokine profiles of accumulated T cells in inflamed skin during titanium allergy.Characterization of the TCR repertoire revealed the presence of the TRAV10/TRAJ18 clonotype, indicative of natural killer T cells, and TRAV1/TRAJ33, associated with mucosal-associated invariant T (MAIT) cells in the inflamed skin of both the irritant and allergic mice models. Thus our murine model of titanium-induced hypersensitivity shows that NKT cells and MAIT cells participate in titanium allergy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K11329","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H05020/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"15K11329.pdf","filesize":[{"value":"451.2 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K11329","url":"https://tsurumi-u.repo.nii.ac.jp/record/1092/files/15K11329.pdf"},"version_id":"6a2da04c-db43-49fc-9605-4f985388358b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"チタンアレルギー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"NK T細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"MAIT細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"HAMADA, Yoshiki","creatorNameLang":"en"},{"creatorName":"濱田, 良樹","creatorNameLang":"ja"},{"creatorName":"ハマダ, ヨシキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"HAMADA","familyNameLang":"en"},{"familyName":"濱田","familyNameLang":"ja"},{"familyName":"ハマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoshiki","givenNameLang":"en"},{"givenName":"良樹","givenNameLang":"ja"},{"givenName":"ヨシキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"746","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70247336","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70247336"},{"nameIdentifier":"746","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"チタンアレルギーの病態機序および生体反応に関わる免疫学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"チタンアレルギーの病態機序および生体反応に関わる免疫学的研究","subitem_title_language":"ja"},{"subitem_title":"Immunological analysis of pathogenesis and immune response in titanium allergy","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1092","relation_version_is_last":true,"title":["チタンアレルギーの病態機序および生体反応に関わる免疫学的研究"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T07:41:02.049367+00:00"}