{"created":"2023-05-15T08:55:51.446747+00:00","id":1087,"links":{},"metadata":{"_buckets":{"deposit":"db48de0a-bb8b-468e-b544-2290173a3b08"},"_deposit":{"created_by":10,"id":"1087","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1087"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001087","sets":["100:101:103:165"]},"author_link":["823"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：メラトニン投与群では象牙芽細胞内のメラトニン受容体MT1の発現がより強かった。メラトニン投与群では象牙芽細胞の背が高く、象牙芽細胞数が増加していた。象牙前質中の石灰化球の数が増加し、大きさも増大していた。象牙質のアパタイト結晶が均一な大きさで規則的に配列し、結晶性がやや向上した。またコラーゲン線維が増加した。メラトニン投与により血清中のCaやP濃度の挙動に変化をもたらし、メラトニン代謝産物の量が増加した。メラトニンが体内の血中組成に変化をもたらし、象牙質や象牙芽細胞に影響を与え、基質のコラーゲン線維の分泌、石灰化機構、アパタイト結晶の結晶性を変化させる可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：The expression of MT1 and MT2 melatonin receptor was confirmed in the odontoblasts of the control group. In addition, the expression of MT1 was stronger than that of MT2. A strong expression of MT1 was detected in the odontoblasts in the melatonin-treated groups. In the melatonin-treated groups, the height of odontoblasts was high and the number of odontoblasts increased. The number and size of calcospherites in predentin increased in proportion to the concentration of melatonin. The crystallinity and orientation of apatite crystal in dentin were improved by administration of melatonin. The odontoblasts were activated by melatonin, and the secretion of collagen fibers was promoted. Melatonin administration changed the behavior of Ca and P concentration in serum at night. Melatonin is efficiently incorporated into odontoblasts. The present study suggests that melatonin changed the blood composition in the body and influenced the structure, calcification, and crystallinity of dentin.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-10-21 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔組織学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K11034","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K11034/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"15K11034.pdf","filesize":[{"value":"110.3 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K11034","url":"https://tsurumi-u.repo.nii.ac.jp/record/1087/files/15K11034.pdf"},"version_id":"e2590337-1bb7-4e8f-a1ba-fc085d822a87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メラトニン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"象牙質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"象牙芽細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アパタイト結晶","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メラトニン受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"石灰化機構","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"石灰化球","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン線維","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"MISHIMA, Hiroyuki","creatorNameLang":"en"},{"creatorName":"三島, 弘幸","creatorNameLang":"ja"},{"creatorName":"ミシマ, ヒロユキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"MISHIMA","familyNameLang":"en"},{"familyName":"三島","familyNameLang":"ja"},{"familyName":"ミシマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroyuki","givenNameLang":"en"},{"givenName":"弘幸","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"823","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30112957","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30112957"},{"nameIdentifier":"823","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"時刻情報伝達物質であるメラトニンによる象牙質の組織構造と象牙芽細胞の制御機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"時刻情報伝達物質であるメラトニンによる象牙質の組織構造と象牙芽細胞の制御機構","subitem_title_language":"ja"},{"subitem_title":"Control mechanism on structure, composition, and calcification of dentin and odontoblasts by time information transmitter melatonin","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1087","relation_version_is_last":true,"title":["時刻情報伝達物質であるメラトニンによる象牙質の組織構造と象牙芽細胞の制御機構"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T00:12:42.038649+00:00"}