{"created":"2023-05-15T08:55:51.386369+00:00","id":1086,"links":{},"metadata":{"_buckets":{"deposit":"aea88c38-7b18-43bf-b0fd-cb73a13d67ab"},"_deposit":{"created_by":10,"id":"1086","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1086"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001086","sets":["100:101:103:165"]},"author_link":["822"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：マウスに35％のＣＲ（カロリー制限食）を与えると唾液分泌量は増加し、若齢マウスを上回った。唾液腺の炎症の程度について検討を行うと、自由摂取群と比較してＣＲマウスでは、浸潤細胞は減少し、組織内で産生される炎症性サイトカインも低値を示し、アミノ酸代謝関連遺伝子にも変動が認められ、さらにＣＲ群ではケトン体が経時的に上昇した。カロリー制限による様々な作用はヒストン脱アセチル化酵素のsirtuinが関与しており、ポリフェノール類のレスベラトロールがこれを活性化することが報告されていることから、レスベラトロールのNODマウスの唾液分泌亢進作用を有する事を確認したことから臨床応用の基盤となる成果が得られた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Calorie restriction (CR) is known to decrease the risk of disease onset resulting in lifespan elongation. Xerostomia is accompanied with aging, however, the pathogenesis is unknown yet and effective treatment has not been established. We studied the effect of CR on xerostomia accompanied with aging.Method Twelve-month-old male C57BL/6 mice were divided into ad libitum-fed (AL) group and CR group. The amount of food intake in CR group was 35% less than in AL group. The saliva secretion was measured after three and six months of CR. At the end of experiment, salivary glands were extracted following histological and gene expression analysis. Results The amount of saliva secretion decreased with aging in AL group, whereas increased saliva secretion was seen from three months after CR. Remarkable lymphocyte infiltration into salivary glands in AL group mice, however, lymphocyte infiltration was not obvious in CR group mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2017(平成29)年度 科学研究費補助金 基盤研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2018-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：病理","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15H05020","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15H05020/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-25"}],"displaytype":"detail","filename":"15H05020.pdf","filesize":[{"value":"656.3 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15H05020","url":"https://tsurumi-u.repo.nii.ac.jp/record/1086/files/15H05020.pdf"},"version_id":"59696822-4e1d-498e-87e1-7c2ffb1c619e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ドライマウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"カロリー制限","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"セリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"NODマウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シェーグレン症候群","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"SAITO, Ichiro","creatorNameLang":"en"},{"creatorName":"斎藤, 一郎","creatorNameLang":"ja"},{"creatorName":"サイトウ, イチロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"SAITO","familyNameLang":"en"},{"familyName":"斎藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ichiro","givenNameLang":"en"},{"givenName":"一郎","givenNameLang":"ja"},{"givenName":"イチロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"822","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60147634","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60147634"},{"nameIdentifier":"822","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"カロリー制限研究からの知見を応用した唾液分泌障害に対する新規治療基盤の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カロリー制限研究からの知見を応用した唾液分泌障害に対する新規治療基盤の確立","subitem_title_language":"ja"},{"subitem_title":"The molecular mechanism of salivary dysfunction amelioration by calorie restriction","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-25"},"publish_date":"2022-03-25","publish_status":"0","recid":"1086","relation_version_is_last":true,"title":["カロリー制限研究からの知見を応用した唾液分泌障害に対する新規治療基盤の確立"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-02T00:10:25.207666+00:00"}