{"created":"2023-05-15T08:55:48.929191+00:00","id":1042,"links":{},"metadata":{"_buckets":{"deposit":"82164677-08ad-4fb2-a398-ff9e3f44da15"},"_deposit":{"created_by":10,"id":"1042","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1042"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001042","sets":["100:101:103:160"]},"author_link":["788"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：再生移植組織および宿主受容組織を非侵襲的に無菌化できる技術開発のための基礎研究として、大気圧低温プラズマを評価することを目的とした。プラズマによって産生される活性種により十分な殺菌活性を示すこと、かつ短時間に活性が消失し残留活性を示さないことを検証した。感染モデルの検証では、照射法よりプラズマ処理水の方がより短時間で非常に高い効果を示した。そこで、移植片受容組織および移植細胞（単層細胞および移植組織シート）モデルでのプラズマ処理水の安全性試験を行った結果、代謝活性障害は認められず、高い安全性が示された。したがって、プラズマ処理水は高い殺菌活性と生体組織安全性を併せ持つと結論された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：This study aimed to evaluate atmospheric low temperature plasma as a basic research for the development of technology that can non-invasively sterilize regenerated transplanted tissues and host recipient tissues. It was verified that the active species produced by the plasma show sufficient bactericidal activity and that the activity disappears in a short time and does not show residual activity. In the verification of the infection model, plasma treated water showed a very high effect in a shorter time than the irradiation method. As a result of conducting a safety test of plasma treated water in a graft recipient tissue and transplanted cell (monolayer cell and graft tissue sheet) model, no metabolic activity failure was observed, and high safety was shown. Therefore, it was concluded that plasma-treated water has high bactericidal activity and biological tissue safety.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2018(平成30)年度 科学研究費補助金 基盤研究(C) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2015-04-01 – 2019-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔微生物学","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 日本の再生医療は臨床での実用化レベルに達しており、再生組織のベースとなるiPS 細胞が高率に分離される歯髄の使用が増加すると思われるが、口腔からの感染と隣り合わせである。しかし既存の消毒薬は組織の損傷・細胞毒性が懸念されるため使用できず、抗菌薬に依存しているため、抗菌薬アレルギー患者は適応外とされているが、そのような症例も等しく再生医療を受けられる必要性に迫られると予想される。プラズマ処理水に含まれる活性種は、検出限界以下まで殺菌する一方で、ほぼ組織毒性を示さないことが今回の研究で明らかとなった。したがって再生医療のみならず、広く医療全般での有用性が期待される。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 15K11229","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K11229/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-16"}],"displaytype":"detail","filename":"15K11229.pdf","filesize":[{"value":"172.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"15K11229","url":"https://tsurumi-u.repo.nii.ac.jp/record/1042/files/15K11229.pdf"},"version_id":"90cb5121-ef18-4747-aeb1-ce090bdb99d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"プラズマ医療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"感染根管モデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"プラズマ処理水","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"殺菌効果","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"生体安全性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"OHSHIMA, Tomoko","creatorNameLang":"en"},{"creatorName":"大島, 朋子","creatorNameLang":"ja"},{"creatorName":"オオシマ, トモコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"OHSHIMA","familyNameLang":"en"},{"familyName":"大島","familyNameLang":"ja"},{"familyName":"オオシマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tomoko","givenNameLang":"en"},{"givenName":"朋子","givenNameLang":"ja"},{"givenName":"トモコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"788","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50233101","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50233101"},{"nameIdentifier":"788","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大気圧低温プラズマ処理を利用した再生医療における低侵襲性の組織無菌化に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大気圧低温プラズマ処理を利用した再生医療における低侵襲性の組織無菌化に関する検討","subitem_title_language":"ja"},{"subitem_title":"Study on minimally invasive tissue sterilization in regenerative medicine using atmospheric pressure low temperature plasma treatment","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["160"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-16"},"publish_date":"2022-03-16","publish_status":"0","recid":"1042","relation_version_is_last":true,"title":["大気圧低温プラズマ処理を利用した再生医療における低侵襲性の組織無菌化に関する検討"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T22:53:31.172633+00:00"}