{"created":"2023-05-15T08:55:48.051784+00:00","id":1025,"links":{},"metadata":{"_buckets":{"deposit":"626d8e8f-eef9-458a-96f4-8b869e2cb1e8"},"_deposit":{"created_by":10,"id":"1025","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1025"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001025","sets":["100:101:103:157"]},"author_link":["782"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):変形性関節症の原因遺伝子であるAsporin遺伝子の発現を比較するためにRT-PCRを行った。その結果Asporin遺伝子の発現が経日的に上昇傾向にあること、またSTRマウスでは、ICRマウスと比較して、下顎頭軟骨および脛骨関節軟骨でAsporinの発現が強い傾向にあり、特に30週齢ではSTRマウスの方が有意に強発現していた。Asporinの免疫組織化学染色を行った。先ほどのPCRの結果と同様Asporinの局在が経日的に強くみられ、またSTRマウスでは、ICRマウスと比較して、Asporinの局在が強くみられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要(英文):Asporin mRNA levels were analyzed using Real-time RT-PCR. Asporin mRNA highly expressed in STR/Ort mice and increased with age, especially 30 weeks. Asporin localized in STR/Ort mice. Asporin signal intensity of immune-reactivity are also highly expressed in STR/Ort mice and increased with age.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2019(令和元)年度 科学研究費補助金 若手研究(B) 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度):2017-04-01 – 2020-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野:歯科矯正","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : これまでの顎関節症研究は臨床、画像診断および対症療法的治療を行うに留まっており、分子レベルでの原因解明は未だされていない。本研究結果によってAsporinが変形性関節症モデルマウスの顎関節に高いレベルで発現していたということは、Asporinは変形性顎関節症の原因となっている可能性が考えられる。本研究テーマは我々歯科の分野の視点から着想に至った先駆的研究であり、今後の関節軟骨研究のエビデンス構築の一助となることが考えられる。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 17K17341","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K17341/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"17K17341.pdf","filesize":[{"value":"476.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"17K17341","url":"https://tsurumi-u.repo.nii.ac.jp/record/1025/files/17K17341.pdf"},"version_id":"c087c311-d096-4f9d-9500-90bc6c2d8724"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"顎関節","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"変形性関節症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Asporin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"STRマウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"RT-PCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IHC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"MIYAMOTO, Yutaka","creatorNameLang":"en"},{"creatorName":"宮本, 豊","creatorNameLang":"ja"},{"creatorName":"ミヤモト, ユタカ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"MIYAMOTO","familyNameLang":"en"},{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yutaka","givenNameLang":"en"},{"givenName":"豊","givenNameLang":"ja"},{"givenName":"ユタカ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"782","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00633588","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00633588"},{"nameIdentifier":"782","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"変形性関節症モデルマウスを用いた顎関節におけるasporinの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"変形性関節症モデルマウスを用いた顎関節におけるasporinの解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of asporin in mandibular condylar cartilage using osteoarthritis model mouse","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["157"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"1025","relation_version_is_last":true,"title":["変形性関節症モデルマウスを用いた顎関節におけるasporinの解析"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:57:02.759039+00:00"}