{"created":"2023-05-15T08:55:46.741590+00:00","id":1000,"links":{},"metadata":{"_buckets":{"deposit":"9e0bc863-df14-4ac5-9c1c-b731adb4d3bf"},"_deposit":{"created_by":10,"id":"1000","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1000"},"status":"published"},"_oai":{"id":"oai:tsurumi-u.repo.nii.ac.jp:00001000","sets":["100:101:103:149"]},"author_link":["758"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-03-31","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 従来、上皮性異形成を検出するためヨード染色法（IOM）が用いられているが、IOMはヨードの粘膜刺激性、ヨードアレルギー患者への適用外、角化粘膜には適用できないという弱点がある。そこで、蛍光観察装置のIllumiScanおよびVELscopeを用い、蛍光観察法 (AVM)の客観的指標として、健常粘膜とFVL部の輝度比からカットオフ値を設定し、病理組織学的診断をゴールドスタンダードとして舌上皮性異形成の検出精度を求め、その臨床応用の可能性についてヨード染色法と比較検証した。客観的AVMは、IOMよりも正診率が高く、舌上皮性異形成の補助検出法として臨床応用できる可能性が示された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"研究成果の概要（英文）：Conventionally, an iodine-staining method (IOM) has been used to detect the oral epithelial dysplasia. However, IOM has several weak points: iodine is irritative to the mucosa, it is contraindicated in patients with allergy to iodine, and it cannot be used in keratinized mucosa. Therefore, using the fluorescence visulaization devices, such as IllumiScan and VELscope, set the cutoff value from the luminance ratio between the healthy tissue and FVL for an objective index of fluorescence visualization method (AVM). To obtain the detection accuracy of epithelial dysplasia of the tongue, we used histopathological diagnosis as the gold standard and examined its clinical application potential in comparison with the iodine-staining method. Objective AVM has a higher accuracy rate than IOM, and it was indicated the possibility of clinical application as an auxiliary detection method for epithelial dysplasia of the tongue.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"・2020(令和2)年度 科学研究費補助金 若手研究 研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究期間 (年度)：2019-04-01 – 2021-03-31","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究分野：口腔外科","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"・研究成果の学術的意義や社会的意義 : 口腔がんは口腔顎顔面領域に発生するため、発見が遅延した場合、外科的な手術が施されたとしても、術後、社会生活に不可欠な摂食嚥下機能、構音機能ならびに審美的機能に著しい低下をきたす。そのため、口腔がんにおいて早期発見早期治療が重要となる。従来、口腔がんおよび上皮性異形成の検出のためにヨード染色法(IOM)が用いられてきたが、IOMにはヨードによる粘膜刺激があり、角化粘膜には適応できないという弱点があり、近年、非接触・非侵襲の蛍光観察法が用いられてきている。しかしながら、現在、蛍光観察装置はさまざまな機器が開発、臨床応用されているが、それらの客観的評価法は未だ確立されておらず、精度も様々である。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号 : 19K19250","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K19250/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-02"}],"displaytype":"detail","filename":"19K19250.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"19K19250","url":"https://tsurumi-u.repo.nii.ac.jp/record/1000/files/19K19250.pdf"},"version_id":"89ddb763-04d5-411e-bc7f-c5bbfaabbff6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"蛍光観察法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"VELscope","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IllumiScan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮性異形成","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔がん","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"NAKAMURA, Nanami","creatorNameLang":"en"},{"creatorName":"中村, 那々美","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ナナミ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"NAKAMURA","familyNameLang":"en"},{"familyName":"中村","familyNameLang":"ja"},{"familyName":"ナカムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Nanami","givenNameLang":"en"},{"givenName":"那々美","givenNameLang":"ja"},{"givenName":"ナナミ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"758","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40824909","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40824909"},{"nameIdentifier":"758","nameIdentifierScheme":"WEKO著者ID"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌発生におけるジェネティック-エピジェネティク制御機構の解明と臨床検査法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌発生におけるジェネティック-エピジェネティク制御機構の解明と臨床検査法の確立","subitem_title_language":"ja"},{"subitem_title":"Elucidation of genetic and epigenetic control mechanisms in cancer development and establishment of clinical examination methods","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"10","path":["149"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-02"},"publish_date":"2022-03-02","publish_status":"0","recid":"1000","relation_version_is_last":true,"title":["癌発生におけるジェネティック-エピジェネティク制御機構の解明と臨床検査法の確立"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-08-01T08:10:27.512747+00:00"}